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    Jon99Ci Jonah 99Ci [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon99Ciprovided by FlyBase
    Official Full Name
    Jonah 99Ciprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003358
    Locus tag
    Dmel_CG31039
    See related
    AllianceGenome:FB:FBgn0003358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143341_at; 99Calpha; CG17951; CG31039; Dmel\CG31039; Jon99B; Jon99C; Jon99C1; Jon99C2; Jon99Calpha; Jon99Calphai; Jon99Cbeta; Jon99Cbetai; JON99CI; JonC; Ser3; SER3; ser99Dc; Ser99Dc; SP150
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon99Ci in Genome Data Viewer
    Location:
    99C7-99C7; 3-99 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29925226..29926189, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25750948..25751911, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Ciii Neighboring gene Jonah 99Cii Neighboring gene uncharacterized protein Neighboring gene alpha-Mannosidase class I c Neighboring gene Component of oligomeric golgi complex 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP. Yun Y, et al. Mol Cell Biol, 1989 Feb. PMID 2469005, Free PMC Article
    2. A bacteria-regulated gut peptide determines host dependence on specific bacteria to support host juvenile development and survival. Lee J, et al. BMC Biol, 2022 Nov 17. PMID 36397042, Free PMC Article
    3. Drosophila C virus systemic infection leads to intestinal obstruction. Chtarbanova S, et al. J Virol, 2014 Dec. PMID 25253354, Free PMC Article
    4. Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Erkosar B, et al. Cell Host Microbe, 2015 Oct 14. PMID 26439865, Free PMC Article
    5. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 99Ci
    Names
    CG31039-PA
    Jon99Ci-PA
    jonah 99 Ci
    jonah 99C alpha
    jonah 99C beta
    serine protease
    serine protease 3
    NP_524555.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29925226..29926189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079831.4 → NP_524555.1  jonah 99Ci [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17207, Q9VAD8
      Related
      FBpp0084877
      Conserved Domains (2) summary
      smart00020
      Location:40 → 264
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:41 → 266
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17207.2 P17207

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