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    CG8679 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8679provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032934
    Locus tag
    Dmel_CG8679
    See related
    AllianceGenome:FB:FBgn0032934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    dLEM3; Dmel\CG8679
    Summary
    Predicted to enable DNA endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination and resolution of meiotic recombination intermediates. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8679 in Genome Data Viewer
    Location:
    39B3-39B3; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21216004..21218544, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21216004..21218544, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene clumsy Neighboring gene Autophagy-related 18b Neighboring gene small nuclear RNA U4 at 39B Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45713 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity. Danilov A, et al. Oncotarget, 2015 Aug 14. PMID 26305987, Free PMC Article
    2. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Abramov YA, et al. Genetics, 2016 Jan. PMID 26500261, Free PMC Article
    3. Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein. Pinto BS, et al. Genetics, 2008 Sep. PMID 18723885, Free PMC Article
    4. Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response. Montana ES, et al. J Biol Chem, 2006 Mar 24. PMID 16415344
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8679-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21216004..21218544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136255.3 → NP_610099.1  uncharacterized protein Dmel_CG8679 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIE0
      Related
      FBpp0081017
      Conserved Domains (5) summary
      smart00540
      Location:404 → 447
      LEM; in nuclear membrane-associated proteins
      cd10454
      Location:513 → 657
      GIY-YIG_COG3680_Meta; GIY-YIG domain of hypothetical proteins from Metazoa
      cd00204
      Location:15 → 133
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13857
      Location:67 → 121
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:42 → 78
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIE0 Q9VIE0

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