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    Mal-A3 Maltase A3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mal-A3provided by FlyBase
    Official Full Name
    Maltase A3provided by FlyBase
    Primary source
    FLYBASE:FBgn0002571
    Locus tag
    Dmel_CG8695
    See related
    AllianceGenome:FB:FBgn0002571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8695; Dmel\CG8695; Drome_A3; L; lvpL; LvpL; mal_A3; V
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-A3 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8455909..8457892, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4343414..4345397, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4e1 Neighboring gene Maltase A1 Neighboring gene Maltase A2 Neighboring gene Maltase A4 Neighboring gene Maltase A5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two gene families clustered in a small region of the Drosophila genome. Snyder M, et al. J Mol Biol, 1983 May 15. PMID 6854639
    2. The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster. Vieira CP, et al. Mol Biol Evol, 1997 Oct. PMID 9335139
    3. Detection of protein similarities using nucleotide sequence databases. Henikoff S, et al. Nucleic Acids Res, 1988 Jul 11. PMID 3135536, Free PMC Article
    4. Comparative Transcriptomic Analysis Revealing the Potential Mechanisms of Erythritol-Caused Mortality and Oviposition Inhibition in Drosophila melanogaster. Li L, et al. Int J Mol Sci, 2024 Mar 27. PMID 38612549, Free PMC Article
    5. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase A3
    Names
    CG8695-PA
    Mal-A3-PA
    gene V
    hdl cuticle gene cluster
    larval visceral protein L
    maltase
    NP_476628.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8455909..8457892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057280.4 → NP_476628.2  maltase A3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476628.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P07192, Q9V4T8
      Related
      FBpp0087837
      Conserved Domains (2) summary
      cd11328
      Location:22 → 490
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      pfam00128
      Location:46 → 400
      Alpha-amylase; Alpha amylase, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07192.2 P07192

    Gene LinkOut

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