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    alphaKap4 alpha Karyopherin-4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alphaKap4provided by FlyBase
    Official Full Name
    alpha Karyopherin-4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035657
    Locus tag
    Dmel_CG10478
    See related
    AllianceGenome:FB:FBgn0035657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10478; CG11040; Dmel\CG10478; g7295403
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alphaKap4 in Genome Data Viewer
    Location:
    65A2-65A2; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6009446..6011021, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6002546..6004121, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45439 Neighboring gene long non-coding RNA:CR45440 Neighboring gene PVR adaptor protein Neighboring gene uncharacterized protein Neighboring gene yippee interacting protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the metazoan-specific importin alpha gene family. Mason DA, et al. J Mol Evol, 2009 Apr. PMID 19308634
    2. Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis. Mason DA, et al. Genetics, 2002 May. PMID 12019231, Free PMC Article
    3. Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. Jang AR, et al. PLoS Genet, 2015 Feb. PMID 25674790, Free PMC Article
    4. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article
    5. Birth, death, and replacement of karyopherins in Drosophila. Phadnis N, et al. Mol Biol Evol, 2012 May. PMID 22160828, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha Karyopherin-4
    Names
    CG10478-PA
    alphaKap4-PA
    importin alpha4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6009446..6011021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139750.2 → NP_648007.1  alpha Karyopherin-4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G9LQY8, G9LQZ0, G9LQZ1, Q9VRS0
      Related
      FBpp0076777
      Conserved Domains (3) summary
      cd00020
      Location:189 → 301
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam16186
      Location:400 → 433
      Arm_3; Atypical Arm repeat
      sd00043
      Location:192 → 217
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRS0 Q9VRS0

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