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    Tpst Tyrosylprotein sulfotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpstprovided by FlyBase
    Official Full Name
    Tyrosylprotein sulfotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086674
    Locus tag
    Dmel_CG32632
    See related
    AllianceGenome:FB:FBgn0086674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1573; CG15758; CG15759; CG32629; CG32629/CG32632; CG32632; Dmel\CG32632; DmTPST; Tango13; TANGO13; TPST
    Old locus tag
    CG15758; CG32629; Dmel_CG15758; Dmel_CG32629
    Summary
    Enables protein-tyrosine sulfotransferase activity. Involved in protein secretion. Located in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1) and TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tpst in Genome Data Viewer
    Location:
    12A4-12A7; 1-44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13563823..13593224)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13457856..13487257)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene upheld Neighboring gene long non-coding RNA:CR44654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fluorescence assay for protein post-translational tyrosine sulfation. Chen BH, et al. Anal Bioanal Chem, 2013 Feb. PMID 23161068
    2. High-Throughput Screening of Sulfated Proteins by Using a Genome-Wide Proteome Microarray and Protein Tyrosine Sulfation System. Huang BY, et al. Anal Chem, 2017 Mar 21. PMID 28211678
    3. Preparation of Tyrosylprotein Sulfotransferases for In Vitro One-Pot Enzymatic Synthesis of Sulfated Proteins/Peptides. Wang CC, et al. ACS Omega, 2018 Sep 30. PMID 30320268, Free PMC Article
    4. Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons. Sun X, et al. G3 (Bethesda), 2015 Oct 28. PMID 26511498, Free PMC Article
    5. Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki). Sturgill D, et al. BMC Bioinformatics, 2013 Nov 9. PMID 24209455, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-tyrosine sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-tyrosine sulfation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosylprotein sulfotransferase
    Names
    CG32632-PB
    CG32632-PC
    CG32632-PD
    CG32632-PE
    CG32632-PF
    CG32632-PG
    Tpst-PB
    Tpst-PC
    Tpst-PD
    Tpst-PE
    Tpst-PF
    Tpst-PG
    transport and golgi organization
    transport and golgi organization 13
    NP_001096973.1
    NP_001259518.1
    NP_001259519.1
    NP_001259520.1
    NP_001259521.1
    NP_727717.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13563823..13593224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272591.1 → NP_001259520.1  tyrosylprotein sulfotransferase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q58CJ7, Q8MM59, Q9VYB7
      UniProtKB/TrEMBL
      M9PEH9
      Conserved Domains (1) summary
      pfam13469
      Location:73 → 264
      Sulfotransfer_3; Sulfotransferase family

    2. NM_001272592.1 → NP_001259521.1  tyrosylprotein sulfotransferase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUV2
      Conserved Domains (1) summary
      pfam13469
      Location:70 → 258
      Sulfotransfer_3; Sulfotransferase family

    3. NM_001272590.1 → NP_001259519.1  tyrosylprotein sulfotransferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUV2
      Conserved Domains (1) summary
      pfam13469
      Location:70 → 258
      Sulfotransfer_3; Sulfotransferase family

    4. NM_001103503.2 → NP_001096973.1  tyrosylprotein sulfotransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUV2
      Conserved Domains (1) summary
      pfam13469
      Location:70 → 258
      Sulfotransfer_3; Sulfotransferase family

    5. NM_167374.3 → NP_727717.1  tyrosylprotein sulfotransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q58CJ7, Q8MM59, Q9VYB7
      UniProtKB/TrEMBL
      M9PEH9
      Related
      FBpp0290842
      Conserved Domains (1) summary
      pfam13469
      Location:73 → 264
      Sulfotransfer_3; Sulfotransferase family

    6. NM_001272589.1 → NP_001259518.1  tyrosylprotein sulfotransferase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHI3
      Conserved Domains (1) summary
      pfam13469
      Location:70 → 258
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUV2 A8JUV2
    M9PEH9 M9PEH9
    M9PHI3 M9PHI3
    Q9VYB7.2 Q9VYB7

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