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    CG6380 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6380provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032632
    Locus tag
    Dmel_CG6380
    See related
    AllianceGenome:FB:FBgn0032632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6380
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Orthologous to several human genes including PPP1R2B (PPP1R2 family member B); PPP1R2C (PPP1R2C family member C); and PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6380 in Genome Data Viewer
    Location:
    36C5-36C5; 2-53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17291075..17292202, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17291075..17292202, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45729 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45696

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. Agrawal P, et al. G3 (Bethesda), 2016 Dec 7. PMID 27784754, Free PMC Article
    2. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    3. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6380-PA
    CG6380-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17291075..17292202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299080.1 → NP_001286009.1  uncharacterized protein Dmel_CG6380, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJE7
      Conserved Domains (1) summary
      pfam04979
      Location:24 → 135
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

    2. NM_135989.2 → NP_609833.1  uncharacterized protein Dmel_CG6380, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJE7
      Related
      FBpp0080523
      Conserved Domains (1) summary
      pfam04979
      Location:24 → 135
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZA9 Q8MZA9
    Q9VJE7 Q9VJE7

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