eIF4EHP eukaryotic translation initiation factor 4E homologous protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF4EHPprovided by FlyBase
Official Full Name: eukaryotic translation initiation factor 4E homologous proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0053100
Locus tag: Dmel_CG33100
See related: AllianceGenome:FB:FBgn0053100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4E-HP; 4EHP; CG10716; CG33100; CT30033; d4eHP; d4EHP; Dmel\CG33100; eIF4E; eIF4E-8
Summary: Enables RNA 7-methylguanosine cap binding activity and mRNA regulatory element binding translation repressor activity. Involved in negative regulation of translation and positive regulation of ecdysteroid biosynthetic process. Part of eukaryotic translation initiation factor 4F complex and translation repressor complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; mesoderm; and neurohemal organ. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24063077..24108960, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19888799..19934682, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia.
Title: eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia.
Consistent with this, 4EHP is highly expressed in the prothoracic gland and it is required for wild type expression levels of steroidogenic enzymes
Title: Drosophila 4EHP is essential for the larval-pupal transition and required in the prothoracic gland for ecdysone biosynthesis.
findings show that the belle RNA is translationally repressed by the d4EHP protein in the Drosophila ovary.
Title: Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors.
By regulating Cad and Hb expression, d4EHP plays a key role in establishing anterior-posterior axis polarity in the Drosophila embryo.
Title: Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
NOT enables eukaryotic initiation factor 4G binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA regulatory element binding translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of translation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ecdysteroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IDA Inferred from Direct Assay more info	PubMed
part_of translation repressor complex	IDA Inferred from Direct Assay more info	PubMed

Preferred Names: eukaryotic translation initiation factor 4E homologous protein

Names: 4EHP; CG33100-PA; CG33100-PB; CG33100-PC; CG33100-PD; eIF4E-Homologous protein; eIF4EHP-PA; eIF4EHP-PB; eIF4EHP-PC; eIF4EHP-PD

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The following sections contain reference sequences that belong to a specific genome build. Explain