U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rad23 Rad23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43785, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rad23provided by FlyBase
    Official Full Name
    Rad23provided by FlyBase
    Primary source
    FLYBASE:FBgn0026777
    Locus tag
    Dmel_CG1836
    See related
    AllianceGenome:FB:FBgn0026777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1836; DHR23; Dmel\CG1836; rad23; RAD23
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in nucleotide-excision repair and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in adult head and organism. Orthologous to several human genes including RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rad23 in Genome Data Viewer
    Location:
    102B3-102B3; 4-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (308093..310822)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (328719..331448)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44023 Neighboring gene Synaptotagmin 7 Neighboring gene Zinc/iron regulated transporter-related protein 102B Neighboring gene Ring finger protein 11 Neighboring gene plasma membrane calcium ATPase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Cloning and characterization of the homologue of the Saccharomyces cerevisiae gene in Drosophila melanogaster]. Nabirochkina EN, et al. Genetika, 1999 Jul. PMID 10519079
    2. Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. Sutton JR, et al. Hum Mol Genet, 2017 Apr 15. PMID 28158474, Free PMC Article
    3. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Jantrapirom S, et al. Int J Mol Sci, 2019 Apr 17. PMID 30999567, Free PMC Article
    4. Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Blount JR, et al. Nat Commun, 2014 Aug 21. PMID 25144244, Free PMC Article
    5. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S
      Title: Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
    2. Through DnaJ-1, our data connect ataxin-3 and Rad23 to protective processes involved with protein folding rather than increased turnover of toxic polyQ species.
      Title: The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Rad23
    Names
    CG1836-PA
    CG1836-PB
    CG1836-PC
    Rad23-PA
    Rad23-PB
    Rad23-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      308093..310822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272123.1 → NP_001259052.1  Rad23, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3W9, Q9XZE0
      Conserved Domains (5) summary
      cd01805
      Location:1 → 76
      RAD23_N; Ubiquitin-like domain of RAD23
      cd14378
      Location:153 → 199
      UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
      cd14427
      Location:371 → 411
      UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
      TIGR00601
      Location:1 → 413
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:242 → 296
      XPC-binding; XPC-binding domain

    2. NM_166752.2 → NP_726561.1  Rad23, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMB7, Q9XZE0
      Related
      FBpp0088190
      Conserved Domains (4) summary
      cd14378
      Location:82 → 128
      UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
      cd14427
      Location:300 → 340
      UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
      TIGR00601
      Location:1 → 342
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:171 → 225
      XPC-binding; XPC-binding domain

    3. NM_143661.3 → NP_651918.2  Rad23, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651918.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3W9, Q9XZE0
      Related
      FBpp0088191
      Conserved Domains (5) summary
      cd01805
      Location:1 → 76
      RAD23_N; Ubiquitin-like domain of RAD23
      cd14378
      Location:153 → 199
      UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
      cd14427
      Location:371 → 411
      UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
      TIGR00601
      Location:1 → 413
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:242 → 296
      XPC-binding; XPC-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMB7 Q8IMB7
    Q9V3W9 Q9V3W9
    Q9XZE0 Q9XZE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous