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    mthl6 methuselah-like 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mthl6provided by FlyBase
    Official Full Name
    methuselah-like 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035789
    Locus tag
    Dmel_CG16992
    See related
    AllianceGenome:FB:FBgn0035789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.127; anon-WO0170980.128; CG16992; Dmel\CG16992; mth16; Mthl6
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in eye disc morphogenetic furrow; leg disc; and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mthl6 in Genome Data Viewer
    Location:
    66A2-66A2; 3-21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7485967..7487918)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7479067..7481018)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 316a1 Neighboring gene Cytochrome P450 4d8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan. West AP Jr, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274391, Free PMC Article
    2. Massive parallel expansions of Methuselah/Methuselah-like receptors in schizophoran Diptera. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2018 Sep. PMID 30058118
    3. Gene Ages, Nomenclatures, and Functional Diversification of the Methuselah/Methuselah-Like GPCR Family in Drosophila and Tribolium. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2016 Dec. PMID 28074535
    4. Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. de Mendoza A, et al. Sci Rep, 2016 Feb 26. PMID 26915348, Free PMC Article
    5. The Drosophila melanogaster methuselah gene: a novel gene with ancient functions. Araújo AR, et al. PLoS One, 2013. PMID 23696853, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methuselah-like 6
    Names
    CG16992-PA
    mth-like 6
    mthl6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7485967..7487918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176295.2 → NP_788473.1  methuselah-like 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VS77
      Related
      FBpp0076503
      Conserved Domains (2) summary
      cd00251
      Location:25 → 197
      Mth_Ecto; The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G ...
      cl21561
      Location:211 → 398
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS77.2 Q9VS77

    Gene LinkOut

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