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    Dbct Dihydrolipoamide branched chain transacylase E2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dbctprovided by FlyBase
    Official Full Name
    Dihydrolipoamide branched chain transacylase E2provided by FlyBase
    Primary source
    FLYBASE:FBgn0030612
    Locus tag
    Dmel_CG5599
    See related
    AllianceGenome:FB:FBgn0030612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5599; dDBT; Dmel\CG5599
    Summary
    Predicted to enable acetyltransferase activity and lipoic acid binding activity. Predicted to contribute to branched-chain alpha-keto acid dehydrogenase activity. Involved in L-leucine catabolic process; isoleucine catabolic process; and valine catabolic process. Predicted to be part of branched-chain alpha-ketoacid dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Used to study maple syrup urine disease. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dbct in Genome Data Viewer
    Location:
    13A10-13A10; 1-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15086125..15088629)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14980158..14982662)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase copper chaperone COX17 Neighboring gene uncharacterized protein Neighboring gene Rab3 GDP-GTP exchange factor Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4s3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction. Tsai HY, et al. Dis Model Mech, 2020 Aug 27. PMID 32680850, Free PMC Article
    2. Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences. Hartig JV, et al. EMBO J, 2009 Oct 7. PMID 19644447, Free PMC Article
    3. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
    4. The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells. Zipper L, et al. Metabolites, 2022 Mar 31. PMID 35448502, Free PMC Article
    5. MicroRNAs as modulators of longevity and the aging process. Kinser HE, et al. Hum Genet, 2020 Mar. PMID 31297598, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to branched-chain alpha-keto acid dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables lipoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in branched-chain amino acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoleucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in valine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of branched-chain alpha-ketoacid dehydrogenase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydrolipoamide branched chain transacylase E2
    Names
    CG5599-PA
    Dbct-PA
    NP_573000.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15086125..15088629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132772.4 → NP_573000.1  dihydrolipoamide branched chain transacylase E2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXY3
      Related
      FBpp0073781
      Conserved Domains (4) summary
      cd06849
      Location:39 → 109
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      PLN02528
      Location:41 → 462
      PLN02528; 2-oxoisovalerate dehydrogenase E2 component
      pfam00198
      Location:248 → 461
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
      pfam02817
      Location:161 → 194
      E3_binding; e3 binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXY3 Q9VXY3

    Gene LinkOut

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