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    p pink [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pprovided by FlyBase
    Official Full Name
    pinkprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086679
    Locus tag
    Dmel_CG9770
    See related
    AllianceGenome:FB:FBgn0086679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9770; dHPS5; Dmel\CG9770; HPS5; NP_649810; snb
    Summary
    Involved in compound eye pigmentation; ommochrome biosynthetic process; and protein targeting to lysosome. Located in cytoplasm. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome and Hermansky-Pudlak syndrome 5. Orthologous to human HPS5 (HPS5 biogenesis of lysosomal organelles complex 2 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    85A5-85A5; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8660903..8670684, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4486625..4489621, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sys1 golgi trafficking protein Neighboring gene uncharacterized protein Neighboring gene belle Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tyrosine-GTA 1-6 Neighboring gene transfer RNA:Tyrosine-GTA 1-7 Neighboring gene transfer RNA:Tyrosine-GTA 1-8 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L19 Neighboring gene Unc50 RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic damage at specific gene loci in Drosophila with betatron X-rays. Alexander ML. Genetics, 1975 Nov. PMID 812774, Free PMC Article
    2. Genetic Studies on DROSOPHILA SIMULANS. III. Autosomal Genes. General Discussion. Sturtevant AH. Genetics, 1921 Mar. PMID 17245963, Free PMC Article
    3. Genetic and developmental relationships between two alkaline phosphatases in Drosophilia melanogaster. Wallis BB, et al. Biochem Genet, 1968 Sep. PMID 5717078
    4. Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the gene. Kemphues KJ, et al. Cell, 1980 Sep. PMID 6773669
    5. Interacting proteins identified by genetic interactions: a missense mutation in alpha-tubulin fails to complement alleles of the testis-specific beta-tubulin gene of Drosophila melanogaster. Hays TS, et al. Mol Cell Biol, 1989 Mar. PMID 2498648, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye pigmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in developmental pigmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye pigment biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommochrome biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to lysosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pink
    Names
    CG9770-PA
    CG9770-PB
    CG9770-PC
    drosophila Hermansky-Pudlak syndrome 5 subunit
    p-PA
    p-PB
    p-PC
    pink-peach
    sunburst

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8660903..8670684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316526.1 → NP_001303455.1  pink, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXI1, Q9VHN9
      UniProtKB/TrEMBL
      U3PV63
      Conserved Domains (3) summary
      COG2319
      Location:17 → 132
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:25 → 63
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:21 → 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001316527.1 → NP_001303456.1  pink, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXI1, Q9VHN9
      UniProtKB/TrEMBL
      U3PV63
      Conserved Domains (3) summary
      COG2319
      Location:17 → 132
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:25 → 63
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:21 → 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_141553.3 → NP_649810.1  pink, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXI1, Q9VHN9
      UniProtKB/TrEMBL
      U3PV63
      Related
      FBpp0081373
      Conserved Domains (3) summary
      COG2319
      Location:17 → 132
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:25 → 63
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:21 → 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHN9.1 Q9VHN9
    U3PV63 U3PV63

    Gene LinkOut

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