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    Ubc7 Ubiquitin conjugating enzyme 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubc7provided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0267384
    Locus tag
    Dmel_CG4443
    See related
    AllianceGenome:FB:FBgn0267384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4443; col; crl; Crl; Dmel\CG4443; Ubc47D; UBC7; UbcD7
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including adult head; cephalic furrow; embryonic/larval midgut; germ layer; and presumptive embryonic/larval central nervous system. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ubc7 in Genome Data Viewer
    Location:
    14F1-14F2; 1-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16593677..16595867)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16487710..16489900)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 3 Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 153kD Neighboring gene mir-4965 stem loop Neighboring gene mushroom bodies tiny Neighboring gene stable intronic sequence RNA 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. courtless, the Drosophila UBC7 homolog, is involved in male courtship behavior and spermatogenesis. Orgad S, et al. Genetics, 2000 Jul. PMID 10880487, Free PMC Article
    2. Transcriptome Analysis of NPFR Neurons Reveals a Connection Between Proteome Diversity and Social Behavior. Ryvkin J, et al. Front Behav Neurosci, 2021. PMID 33867948, Free PMC Article
    3. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article
    4. Drosophila cardiac tube organogenesis requires multiple phases of Hox activity. Perrin L, et al. Dev Biol, 2004 Aug 15. PMID 15282158
    5. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 7
    Names
    CG4443-PA
    CG4443-PB
    Ubc7-PA
    Ubc7-PB
    Ubiquitin-conjugating-enzyme-47D
    courtless
    NP_001285334.1
    NP_524684.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16593677..16595867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298405.1 → NP_001285334.1  ubiquitin conjugating enzyme 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXE8
      Conserved Domains (2) summary
      COG5078
      Location:1 → 163
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:8 → 159
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_079945.4 → NP_524684.2  ubiquitin conjugating enzyme 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524684.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXE8
      Related
      FBpp0074058
      Conserved Domains (2) summary
      COG5078
      Location:1 → 163
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:8 → 159
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N9Z5 Q9N9Z5
    Q9VXE8 Q9VXE8

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