U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kat60 Katanin 60 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53566, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kat60provided by FlyBase
    Official Full Name
    Katanin 60provided by FlyBase
    Primary source
    FLYBASE:FBgn0040208
    Locus tag
    Dmel_CG10229
    See related
    AllianceGenome:FB:FBgn0040208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10229; Dm-Kat60; DmCG10229; Dmel\CG10229; kat-60; Kat-60; kat60; katanin-60; Katanin-60; katanin60-dm
    Summary
    Enables microtubule severing ATPase activity and myosin binding activity. Involved in several processes, including dendrite development; microtubule cytoskeleton organization; and regulation of synaptic assembly at neuromuscular junction. Located in several cellular components, including cell cortex; cell leading edge; and microtubule cytoskeleton. Is expressed in organism. Orthologous to several human genes including KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Kat60 in Genome Data Viewer
    Location:
    82F6-82F6; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5227289..5232209, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1053011..1057931, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 37B Neighboring gene Mms19 Neighboring gene retinophilin Neighboring gene Cathepsin F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila katanin-60 depolymerizes and severs at microtubule defects. Díaz-Valencia JD, et al. Biophys J, 2011 May 18. PMID 21575578, Free PMC Article
    2. Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration. Zhang D, et al. Nat Cell Biol, 2011 Apr. PMID 21378981, Free PMC Article
    3. The non-catalytic domains of Drosophila katanin regulate its abundance and microtubule-disassembly activity. Grode KD, et al. PLoS One, 2015. PMID 25886649, Free PMC Article
    4. α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila. Niu X, et al. PLoS One, 2023. PMID 36827311, Free PMC Article
    5. Spastin's microtubule-binding properties and comparison to katanin. Eckert T, et al. PLoS One, 2012. PMID 23272056, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of spastin's microtubule-binding properties and comparison with katanin
      Title: Spastin's microtubule-binding properties and comparison to katanin.
    2. Katanin (p60), believed to be the first discovered severing enzyme, binds and severs microtubules via single molecule total internal reflection fluorescence microscopy.
      Title: Drosophila katanin-60 depolymerizes and severs at microtubule defects.
    3. Data suggest that Drosophila Katanin 60 removes tubulin from microtubule lattice or microtubule ends that contact specific cortical sites to prevent stable and/or lateral attachments.
      Title: Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration.
    4. Katanin appears to function primarily on anaphase chromosomes, where it stimulates microtubule plus-end depolymerization and Pacman-based chromatid motility.
      Title: Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule severing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    katanin 60
    Names
    CG10229-PA
    CG10229-PB
    Kat60-PA
    Kat60-PB
    Katanin-60
    katanin
    NP_001262276.1
    NP_524997.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5227289..5232209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080258.4 → NP_524997.2  katanin 60, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524997.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ40, Q9VN89
      Related
      FBpp0078469
      Conserved Domains (5) summary
      smart00382
      Location:325 → 463
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:329 → 462
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:537 → 570
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam12941
      Location:130 → 210
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      cl21455
      Location:292 → 348
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001275347.1 → NP_001262276.1  katanin 60, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFL3, Q8SZ40
      Conserved Domains (5) summary
      smart00382
      Location:358 → 496
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:362 → 495
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:570 → 603
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam12941
      Location:163 → 243
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      cl21455
      Location:325 → 381
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFL3 A0A0B4KFL3
    Q8SZ40 Q8SZ40
    Q9NHF1 Q9NHF1
    Q9VN89 Q9VN89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools