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    Octbeta3R Octopamine beta3 receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3885573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Octbeta3Rprovided by FlyBase
    Official Full Name
    Octopamine beta3 receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250910
    Locus tag
    Dmel_CG42244
    See related
    AllianceGenome:FB:FBgn0250910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.187; anon-WO0170980.188; CG18554; CG31348; CG31350; CG31351; CG33959; CG34055; CG42244; CG7078; DmCG7078; Dmel\CG42244; DmOctbeta3R; Octb3R; OctBeta3; octbeta3r; octbeta3R; octRbeta3
    Old locus tag
    Dmel_CG18554; Dmel_CG33959; Dmel_CG34055
    Summary
    Enables octopamine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult brain; epithelial tube; ganglia; and mushroom body. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Octbeta3R in Genome Data Viewer
    Location:
    87B15-87C1; 3-52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12511570..12548229, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8337292..8373951, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Heat shock protein 70 Bc Neighboring gene long non-coding RNA:CR46016 Neighboring gene Hugin Neighboring gene Octopamine beta2 receptor Neighboring gene mir-284 stem loop Neighboring gene long non-coding RNA:CR46017

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. Ohhara Y, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605909, Free PMC Article
    2. Expression of β-adrenergic-like octopamine receptors during Drosophila development. Ohhara Y, et al. Zoolog Sci, 2012 Feb. PMID 22303848
    3. Genetic and Neurobiological Analyses of the Noradrenergic-like System in Vulnerability to Sugar Overconsumption Using a Drosophila Model. Branch A, et al. Sci Rep, 2017 Dec 15. PMID 29247240, Free PMC Article
    4. The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level. Perez-Mockus G, et al. Dev Cell, 2023 Oct 23. PMID 37769663, Free PMC Article
    5. Octopamine signaling via OctαR is essential for a well-orchestrated climbing performance of adult Drosophila melanogaster. El-Kholy SE, et al. Sci Rep, 2022 Aug 18. PMID 35982189, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Octss3R)-dependent circuit mechanism selectively regulates appetite for soft sugar media.
      Title: Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables octopamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables octopamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables octopamine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    octopamine beta3 receptor
    Names
    CG42244-PF
    CG42244-PG
    CG42244-PJ
    CG42244-PK
    Octbeta3R-PF
    Octbeta3R-PG
    Octbeta3R-PJ
    Octbeta3R-PK
    octopamine receptor beta3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12511570..12548229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038954.2 → NP_001034043.2  octopamine beta3 receptor, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034043.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4LBB6
      Conserved Domains (2) summary
      pfam00001
      Location:156 → 412
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:146 → 346
      7tm_4; Olfactory receptor

    2. NM_001038957.3 → NP_001034046.3  octopamine beta3 receptor, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034046.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4LBB6
      Conserved Domains (2) summary
      pfam00001
      Location:156 → 344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:146 → 346
      7tm_4; Olfactory receptor

    3. NM_141953.3 → NP_650210.2  octopamine beta3 receptor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650210.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4LBB6
      Conserved Domains (2) summary
      pfam00001
      Location:156 → 344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:146 → 346
      7tm_4; Olfactory receptor

    4. NM_001038959.3 → NP_001034048.2  octopamine beta3 receptor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034048.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0AVV1, Q2PDR1, Q2PDR2, Q2PDR3, Q2PDR4, Q2PDR5, Q2PDR6, Q4LBB5, Q4LBB6, Q4LBB7, Q4LBB8, Q8INI6, Q8INI7, Q9VG56, Q9VG57
      Conserved Domains (2) summary
      pfam00001
      Location:156 → 344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:146 → 346
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4LBB6.4 Q4LBB6

    Gene LinkOut

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