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    wac wee Augmin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wacprovided by FlyBase
    Official Full Name
    wee Augminprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035120
    Locus tag
    Dmel_CG13879
    See related
    AllianceGenome:FB:FBgn0035120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13879; Dgt8; Dmel\CG13879; Wac; was
    Summary
    Enables microtubule binding activity. Involved in cell division; mitotic spindle-templated microtubule nucleation; and spindle assembly involved in female meiosis. Located in meiotic spindle. Part of HAUS complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wac in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (258176..259097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (258176..259097)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Enhancer of bithorax Neighboring gene methuselah-like 14 Neighboring gene DISCO Interacting Protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tudor staphylococcal nuclease

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Mitotic spindle formation mediated by augmin protein complex]. Uehara R, et al. Tanpakushitsu Kakusan Koso, 2009 Nov. PMID 19894586
    2. Differing requirements for Augmin in male meiotic and mitotic spindle formation in Drosophila. Savoian MS, et al. Open Biol, 2014 May. PMID 24829288, Free PMC Article
    3. A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes. Romé P, et al. J Cell Biol, 2018 Oct 1. PMID 30087124, Free PMC Article
    4. Conservation of the behavioral and transcriptional response to social experience among Drosophilids. Shultzaberger RK, et al. Genes Brain Behav, 2019 Jan. PMID 29797548, Free PMC Article
    5. Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytes. Colombié N, et al. PLoS Genet, 2013 Jun. PMID 23785300, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
      Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
    2. Results show that Augmin and gamma-tubulin are required for microtubule nucleation and acentrosomal spindle formation.
      Title: Differing requirements for Augmin in male meiotic and mitotic spindle formation in Drosophila.
    3. meiosis-specific regulation of Augmin compensates for the lack of centrosomes in oocytes by actively biasing sites of microtubule generation within the spindle.
      Title: Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytes.
    4. It mediates mitotic spindle formation. (review)
      Title: [Mitotic spindle formation mediated by augmin protein complex].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wee augmin
    Names
    CG13879-PB
    CG13879-PC
    CG13879-PD
    augmin
    wac-PB
    wac-PC
    wac-PD
    wee-augmin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      258176..259097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274265.1 → NP_001261194.1  wee augmin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JHV2, Q9W0S8
      UniProtKB/TrEMBL
      B3DNG8

    2. NM_138176.3 → NP_612020.2  wee augmin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612020.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JHV2, Q9W0S8
      UniProtKB/TrEMBL
      B3DNG8

    3. NM_001169835.1 → NP_001163306.1  wee augmin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNG8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0S8.2 Q9W0S8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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