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    clos closca [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    closprovided by FlyBase
    Official Full Name
    closcaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261016
    Locus tag
    Dmel_CG42600
    See related
    AllianceGenome:FB:FBgn0261016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12927; CG12928; CG1863; CG33479; CG34364; CG42600; Dmel\CG42600
    Old locus tag
    CG12927; CG1863; CG33479; Dmel_CG12927; Dmel_CG12928; Dmel_CG1863; Dmel_CG33479; Dmel_CG34364
    Summary
    Involved in axis specification; torso signaling pathway; and vitelline membrane formation involved in chorion-containing eggshell formation. Located in extracellular region. Is expressed in oocyte and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 98; ectodermal dysplasia 14; and tooth agenesis. Orthologous to human TSPEAR (thrombospondin type laminin G domain and EAR repeats). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See clos in Genome Data Viewer
    Location:
    45F5-45F6; 2-61 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9587953..9599732, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5475458..5487237, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L31 Neighboring gene uncharacterized protein Neighboring gene Microtubule-associated protein 60 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins in Drosophila. Mineo A, et al. Genetics, 2017 Apr. PMID 28179368, Free PMC Article
    2. closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition. Ventura G, et al. Dev Biol, 2010 Aug 1. PMID 20457146
    3. Conserved and divergent elements in Torso RTK activation in Drosophila development. Grillo M, et al. Sci Rep, 2012. PMID 23094137, Free PMC Article
    4. Organization and regulation of sex-specific thioredoxin encoding genes in the genus Drosophila. Svensson MJ, et al. Dev Genes Evol, 2007 Sep. PMID 17701050
    5. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in terminal region determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in torso signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vitelline membrane formation involved in chorion-containing eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    closca
    Names
    CG42600-PD
    clos-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9587953..9599732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103776.3 → NP_001097246.3  closca [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097246.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DQW8
      Conserved Domains (1) summary
      pfam03736
      Location:263 → 315
      EPTP; EPTP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DQW8 A8DQW8

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