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    Liprin-beta Liprin-beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Liprin-betaprovided by FlyBase
    Official Full Name
    Liprin-betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036376
    Locus tag
    Dmel_CG10743
    See related
    AllianceGenome:FB:FBgn0036376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10743; Dmel\CG10743; liprin
    Summary
    Enables protein homodimerization activity. Involved in axon target recognition; regulation of synapse assembly; and synaptic assembly at neuromuscular junction. Part of protein-containing complex. Is active in neuromuscular junction. Is expressed in eye disc; eye disc morphogenetic furrow; and organism. Orthologous to several human genes including PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Liprin-beta in Genome Data Viewer
    Location:
    70B4-70B4; 3-40 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13513254..13516276)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13506354..13509376)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Spt20 Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 36 Neighboring gene long non-coding RNA:CR45825 Neighboring gene long non-coding RNA:CR45178 Neighboring gene bruno 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three Drosophila liprins interact to control synapse formation. Astigarraga S, et al. J Neurosci, 2010 Nov 17. PMID 21084592, Free PMC Article
    2. PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation. Arnés M, et al. Mol Biol Cell, 2020 Feb 15. PMID 31877058, Free PMC Article
    3. Loss of syd-1 from R7 neurons disrupts two distinct phases of presynaptic development. Holbrook S, et al. J Neurosci, 2012 Dec 12. PMID 23238725, Free PMC Article
    4. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article
    5. Identification of proteasome components required for apical localization of Chaoptin using functional genomics. Yano H, et al. J Neurogenet, 2012 Mar. PMID 22417167

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Liprin-beta
    Names
    CG10743-PA
    CG10743-PB
    CG10743-PC
    Liprin-beta-PA
    Liprin-beta-PB
    Liprin-beta-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13513254..13516276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168556.1 → NP_729920.1  Liprin-beta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU88
      Related
      FBpp0075555, FBtr0075813
      Conserved Domains (4) summary
      cd09563
      Location:357 → 422
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:438 → 499
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:529 → 600
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:530 → 599
      SAM; Sterile alpha motif

    2. NM_140404.2 → NP_648661.1  Liprin-beta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU88
      Related
      FBpp0075556
      Conserved Domains (4) summary
      cd09563
      Location:357 → 422
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:438 → 499
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:529 → 600
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:530 → 599
      SAM; Sterile alpha motif

    3. NM_001274877.1 → NP_001261806.1  Liprin-beta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU88
      Conserved Domains (4) summary
      cd09563
      Location:357 → 422
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:438 → 499
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:529 → 600
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:530 → 599
      SAM; Sterile alpha motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU88 Q9VU88

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