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    sro shroud [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sroprovided by FlyBase
    Official Full Name
    shroudprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262112
    Locus tag
    Dmel_CG12068
    See related
    AllianceGenome:FB:FBgn0262112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12068; Dmel\CG12068; Sro
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in ecdysone biosynthetic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in nurse cell; organism; ovary; and prothoracic gland. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sro in Genome Data Viewer
    Location:
    99C1-99C1; 3-99 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29794597..29795805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25620319..25621527)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene kayak Neighboring gene long non-coding RNA:CR46110 Neighboring gene fos intronic gene Neighboring gene R and B Neighboring gene Death related ICE-like caspase Neighboring gene Electron transfer flavoprotein beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila. Shimada-Niwa Y, et al. Nat Commun, 2014 Dec 15. PMID 25502946, Free PMC Article
    2. The gene structure of the Drosophila melanogaster proto-oncogene, kayak, and its nested gene, fos-intronic gene. Hudson SG, et al. Gene, 2008 Aug 15. PMID 18571877
    3. Characterization of candidate intermediates in the Black Box of the ecdysone biosynthetic pathway in Drosophila melanogaster: Evaluation of molting activities on ecdysteroid-defective larvae. Saito J, et al. J Insect Physiol, 2016 Oct-Nov. PMID 27662806
    4. Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the 'Black Box' of the ecdysteroid biosynthesis pathway. Niwa R, et al. Development, 2010 Jun. PMID 20501590
    5. Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development. Zhao Y, et al. BMC Biol, 2021 Sep 3. PMID 34479564, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    shroud
    Names
    CG12068-PA
    sro-PA
    NP_651725.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29794597..29795805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143468.2 → NP_651725.1  shroud [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I3VPX6, Q9VAH3
      Related
      FBpp0084847
      Conserved Domains (2) summary
      cd05374
      Location:27 → 300
      17beta-HSD-like_SDR_c; 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs
      pfam00106
      Location:28 → 229
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAH3 Q9VAH3

    Gene LinkOut

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