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    CG15358 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15358provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031373
    Locus tag
    Dmel_CG15358
    See related
    AllianceGenome:FB:FBgn0031373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15358; mdcds_4396
    Summary
    Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Predicted to be involved in immune response. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in 3MC syndrome 3; asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to several human genes including COLEC10 (collectin subfamily member 10); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15358 in Genome Data Viewer
    Location:
    22B4-22B4; 2-3 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1882008..1883214, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1882201..1884059, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44075 Neighboring gene uncharacterized protein Neighboring gene WD repeat domain 62 Neighboring gene transfer RNA:Glycine-GCC 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An endogenous Drosophila receptor for glycans bearing alpha 1,3-linked core fucose residues. Bouyain S, et al. J Biol Chem, 2002 Jun 21. PMID 11960993
    2. Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity. Dodd RB, et al. Glycobiology, 2001 May. PMID 11425795
    3. FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains. Pei J, et al. J Mol Biol, 2018 Sep 14. PMID 29890119
    4. Comparative genomic analysis of C-type lectin-domain genes in seven holometabolous insect species. Lu Y, et al. Insect Biochem Mol Biol, 2020 Nov. PMID 32841718
    5. Participation of a galactose-specific C-type lectin in Drosophila immunity. Tanji T, et al. Biochem J, 2006 May 15. PMID 16475980, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15358-PD
    CG15358-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1882008..1883214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316377.2 → NP_001303306.2  uncharacterized protein Dmel_CG15358, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ53
      Conserved Domains (1) summary
      cd00037
      Location:141 → 245
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    2. NM_134785.4 → NP_608629.3  uncharacterized protein Dmel_CG15358, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ53
      Conserved Domains (1) summary
      cd00037
      Location:141 → 245
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ53 Q9VQ53

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