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    Dhit Double hit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37037, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhitprovided by FlyBase
    Official Full Name
    Double hitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028743
    Locus tag
    Dmel_CG5036
    See related
    AllianceGenome:FB:FBgn0028743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5036; dhit; Dmel\CG5036; EG:52C10.2
    Summary
    Enables G-protein alpha-subunit binding activity; GDP-dissociation inhibitor activity; and GTPase activator activity. Is expressed in adult head. Orthologous to several human genes including RGS17 (regulator of G protein signaling 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhit in Genome Data Viewer
    Location:
    54E9-54E10; 2-84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17792870..17800677)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13680375..13688182)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45270 Neighboring gene adrift Neighboring gene Ubiquitin conjugating enzyme 10 Neighboring gene uncharacterized protein Neighboring gene grainy head Neighboring gene olf186-M Neighboring gene orai

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray diffraction studies of Drosophila melanogaster Gαo-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036. Tishchenko S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Jan 1. PMID 23295489, Free PMC Article
    2. Double suppression of the Gα protein activity by RGS proteins. Lin C, et al. Mol Cell, 2014 Feb 20. PMID 24560274
    3. Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity. Lin C, et al. PLoS One, 2013. PMID 24204696, Free PMC Article
    4. Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Mohr SE, et al. Genetics, 2002 Sep. PMID 12242231, Free PMC Article
    5. Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases. Kline RA, et al. PLoS Genet, 2017 Mar. PMID 28362802, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    double hit
    Names
    CG5036-PB
    CG5036-PC
    Dhit-PB
    Dhit-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17792870..17800677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299621.1 → NP_001286550.1  double hit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFL6, O96842
      Conserved Domains (1) summary
      cd08718
      Location:136 → 253
      RGS_RZ-like; Regulator of G protein signaling (RGS) domain found in the RZ protein

    2. NM_137427.4 → NP_611271.3  double hit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611271.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB04, O96842, Q8T017
      Conserved Domains (1) summary
      cd08718
      Location:139 → 256
      RGS_RZ-like; Regulator of G protein signaling (RGS) domain found in the RZ protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFL6 A0A0B4LFL6
    O96842 O96842
    Q8T017 Q8T017

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