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    BobA Brother of Bearded A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BobAprovided by FlyBase
    Official Full Name
    Brother of Bearded Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040487
    Locus tag
    Dmel_CG12487
    See related
    AllianceGenome:FB:FBgn0040487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bob; Bob-A; bobA; CG12487; Dmel\CG12487
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in several processes, including defense response to bacterium; negative regulation of Notch signaling pathway; and sensory organ precursor cell fate determination. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BobA in Genome Data Viewer
    Location:
    71A2-71A2; 3-42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14945499..14946125, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14938599..14939225, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Doublecortin-domain-containing echinoderm-microtubule-associated protein Neighboring gene long non-coding RNA:CR45978 Neighboring gene uncharacterized protein Neighboring gene Twin of m4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Duplication and gene conversion in the Drosophila melanogaster genome. Osada N, et al. PLoS Genet, 2008 Dec. PMID 19079581, Free PMC Article
    2. Insight into Notch Signaling Steps That Involve pecanex from Dominant-Modifier Screens in Drosophila. Yamakawa T, et al. Genetics, 2018 Aug. PMID 29853475, Free PMC Article
    3. Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila. Chanet S, et al. Nat Cell Biol, 2012 Apr 15. PMID 22504274
    4. Notch regulates the switch from symmetric to asymmetric neural stem cell division in the Drosophila optic lobe. Egger B, et al. Development, 2010 Sep. PMID 20685734, Free PMC Article
    5. Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Fontana JR, et al. Dev Biol, 2009 Sep 15. PMID 19580805, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ precursor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brother of bearded A
    Names
    BobA-PA
    CG12487-PA
    brother of bearded

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14945499..14946125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080348.3 → NP_525087.2  brother of bearded A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525087.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P83262, Q9V3G5, Q9VUI4
      Related
      FBpp0075426
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83262 P83262

    Gene LinkOut

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