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    alpha-Man-Ic alpha-Mannosidase class I c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Man-Icprovided by FlyBase
    Official Full Name
    alpha-Mannosidase class I cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051202
    Locus tag
    Dmel_CG31202
    See related
    AllianceGenome:FB:FBgn0051202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31202; CG7880; dMas-2; Dmel\CG31202; mas-2
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1); MAN1A2 (mannosidase alpha class 1A member 2); and MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Man-Ic in Genome Data Viewer
    Location:
    99C7-99C7; 3-99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29928701..29930386, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25754423..25756108, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Cii Neighboring gene Jonah 99Ci Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2B subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
    2. Mgat1-dependent N-glycosylation of membrane components primes Drosophila melanogaster blood cells for the cellular encapsulation response. Mortimer NT, et al. PLoS Pathog, 2012. PMID 22829770, Free PMC Article
    3. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
    4. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
    5. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-Mannosidase class I c
    Names
    CG31202-PA
    alpha-Man-Ic-PA
    NP_733331.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29928701..29930386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170452.3 → NP_733331.1  alpha-Mannosidase class I c [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMK0
      Related
      FBpp0084876
      Conserved Domains (1) summary
      pfam01532
      Location:78 → 512
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMK0 Q8IMK0

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