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    yki yorkie [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37851, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ykiprovided by FlyBase
    Official Full Name
    yorkieprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034970
    Locus tag
    Dmel_CG4005
    See related
    AllianceGenome:FB:FBgn0034970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4005; Dmel\CG4005; yap; Yap; YAP; Yap/Taz; Yki; YKI; Yorkie
    Summary
    Enables several functions, including 14-3-3 protein binding activity; kinase binding activity; and transcription coactivator activity. Involved in several processes, including R8 cell development; epithelial cell differentiation; and regulation of cell development. Located in cytosol; lateral cell cortex; and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including CNS glial cell; cortical zone of lymph gland primary lobe; crystal cell primordium; embryonic/larval crystal cell; and embryonic/larval optic stalk. Used to study cancer (multiple); heart disease; nephrolithiasis; and neurodegenerative disease. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to several human genes including YAP1 (Yes1 associated transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See yki in Genome Data Viewer
    Location:
    60B7-60B8; 2-106 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24065975..24068485, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19953498..19956008, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L12 Neighboring gene Ribosomal protein L39 Neighboring gene Ras-associated protein 2-like Neighboring gene Glycerol-3-phosphate acyltransferase 4 Neighboring gene Muscle LIM protein at 60A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forced into shape: Mechanical forces in Drosophila development and homeostasis. Paci G, et al. Semin Cell Dev Biol, 2021 Dec. PMID 34092509, Free PMC Article
    2. Protocol to analyze Drosophila intestinal tumor cellular heterogeneity using immunofluorescence imaging and nuclear size quantification. Pranoto IKA, et al. STAR Protoc, 2024 Jun 21. PMID 38470911, Free PMC Article
    3. Ca(2+)-calpains axis regulates Yki stability and activity in Drosophila. Zhai C, et al. J Genet Genomics, 2024 Oct. PMID 38663479
    4. Mutant analysis by rescue gene excision: New tools for mosaic studies in Drosophila. Zhou Q, et al. Genesis, 2016 Nov. PMID 27696669, Free PMC Article
    5. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Zhao B, et al. Cancer Res, 2009 Feb 1. PMID 19141641

    See all (744) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
      Title: Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
    2. Ca[2+]-calpains axis regulates Yki stability and activity in Drosophila.
      Title: Ca(2+)-calpains axis regulates Yki stability and activity in Drosophila.
    3. Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila.
      Title: Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila.
    4. Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
      Title: Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
    5. Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence.
      Title: Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence.
    6. JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
      Title: JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
    7. Modulation of Yorkie activity by alternative splicing is required for developmental stability.
      Title: Modulation of Yorkie activity by alternative splicing is required for developmental stability.
    8. Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila.
      Title: Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila.
    9. The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
      Title: The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
    10. Silence of yki by miR-7 regulates the Hippo pathway.
      Title: Silence of yki by miR-7 regulates the Hippo pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R8 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apical protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell competition in a multicellular organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelial sheet IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    yorkie
    Names
    CG4005-PD
    CG4005-PF
    CG4005-PG
    CG4005-PH
    yki-PD
    yki-PF
    yki-PG
    yki-PH
    yorki

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24065975..24068485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166657.5 → NP_726414.3  yorkie, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726414.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVH0, A2RVH4, Q0E8X1, Q45VV3, Q7KVG6, Q95TU5, Q9W1B6
      UniProtKB/TrEMBL
      A0A0C4DHD4
      Conserved Domains (2) summary
      pfam00397
      Location:243 → 272
      WW; WW domain
      pfam15238
      Location:57 → 100
      FAM181; FAM181

    2. NM_138035.3 → NP_611879.4  yorkie, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611879.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q45VV3
      Conserved Domains (2) summary
      pfam00397
      Location:243 → 272
      WW; WW domain
      pfam15238
      Location:57 → 100
      FAM181; FAM181

    3. NM_001363931.1 → NP_001350857.1  yorkie, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNA4
      Conserved Domains (2) summary
      COG5021
      Location:261 → 404
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:266 → 295
      WW; WW domain

    4. NM_001043103.2 → NP_001036568.2  yorkie, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036568.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVH0, A2RVH4, Q0E8X1, Q45VV3, Q7KVG6, Q95TU5, Q9W1B6
      UniProtKB/TrEMBL
      A0A0C4DHD4
      Conserved Domains (2) summary
      pfam00397
      Location:243 → 272
      WW; WW domain
      pfam15238
      Location:57 → 100
      FAM181; FAM181
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHD4 A0A0C4DHD4
    H0RNA4 H0RNA4
    Q45VV3.2 Q45VV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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