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    nero nero [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    neroprovided by FlyBase
    Official Full Name
    neroprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261479
    Locus tag
    Dmel_CG2245
    See related
    AllianceGenome:FB:FBgn0261479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2245; Dmel\CG2245; DOHH; l(3)s1921
    Summary
    Enables deoxyhypusine monooxygenase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Located in endoplasmic reticulum membrane. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nero in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31746445..31747558, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27572167..27573280, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tubulin binding cofactor A Neighboring gene uncharacterized protein Neighboring gene abnormal wing discs Neighboring gene uncharacterized protein Neighboring gene salty dog Neighboring gene mir-1014 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Patel PH, et al. J Cell Biol, 2009 Jun 29. PMID 19546244, Free PMC Article
    2. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
    3. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article
    4. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. Daneshvar K, et al. Biol Open, 2013 Jan 15. PMID 23336071, Free PMC Article
    5. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deoxyhypusine monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyhypusine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyhypusine monooxygenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables deoxyhypusine monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine modification to peptidyl-hypusine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-lysine modification to peptidyl-hypusine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nero
    Names
    CG2245-PA
    deoxyhypusine hydroxylase
    lethal (3) s1921
    nero-PA
    NP_651887.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31746445..31747558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143630.2 → NP_651887.1  nero [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651887.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9U4
      Related
      FBpp0085222
      Conserved Domains (3) summary
      smart00567
      Location:85 → 114
      EZ_HEAT; E-Z type HEAT repeats
      pfam13646
      Location:43 → 126
      HEAT_2; HEAT repeats
      sd00044
      Location:39 → 67
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9U4.1 Q9V9U4

    Gene LinkOut

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