PGRP-SC2 Peptidoglycan recognition protein SC2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-SC2provided by FlyBase
Official Full Name: Peptidoglycan recognition protein SC2provided by FlyBase
Primary source: FLYBASE:FBgn0043575
Locus tag: Dmel_CG14745
See related: AllianceGenome:FB:FBgn0043575
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14745; CG14745 PGRP; Dmel\CG14745; PCRP-SC2; PGRP SC; pgrp-sc; PGRP-SC; pgrp-sc2
Summary: Predicted to enable N-acetylmuramoyl-L-alanine amidase activity. Involved in Toll receptor ligand protein activation cascade; negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; and negative regulation of peptidoglycan recognition protein signaling pathway. Is expressed in embryonic/larval gut and embryonic/larval proventriculus. Orthologous to human PGLYRP1 (peptidoglycan recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8716950..8717695)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4604455..4605200)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylmuramoyl-L-alanine amidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG14745-PA; PGRP-SC2-PA; Peptidoglycan-recognition protein-SC2 precursor

NP_610410.1

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The following sections contain reference sequences that belong to a specific genome build. Explain