Cenp-C Centromeric protein-C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cenp-Cprovided by FlyBase
Official Full Name: Centromeric protein-Cprovided by FlyBase
Primary source: FLYBASE:FBgn0266916
Locus tag: Dmel_CG31258
See related: AllianceGenome:FB:FBgn0266916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cenp-C; CENP-C; CenpC; CG11745; CG11746; CG31258; CLD1; dCENP-C; dCenpC; Dmel\CG31258; l(2)SH3 157; l(3)85Aa; l(3)SH157; L1
Summary: Involved in several processes, including kinetochore assembly; nuclear chromosome segregation; and regulation of centromere complex assembly. Located in kinetochore. Is expressed in embryonic brain; gonad; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85A3-85A3; 3-48 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8564105..8569248)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4389827..4394970)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A dynamic population of prophase CENP-C is required for meiotic chromosome segregation.
Title: A dynamic population of prophase CENP-C is required for meiotic chromosome segregation.
CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells.
Title: CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells.
Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Title: Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Cid duplication (leading to Cid6) within the Drosophila subgenus and show that not only Cid, but also Cenp-C is duplicated in the entire subgenus.
Title: Concurrent Duplication of Drosophila Cid and Cenp-C Genes Resulted in Accelerated Evolution and Male Germline-Biased Expression of the New Copies.
centromere assembly factors CAL1 and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility
Title: Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis.
The binding of Flfl to CENP-C is required to bring PP4 activity to centromeres to maintain CENP-C and attached core kinetochore proteins at chromosomes during mitosis.
Title: Centromeric binding and activity of Protein Phosphatase 4.
Centromere proteins CENP-C and CAL1 are required in Drosophila meiosis for centromere pairing and clustering at the nucleolus.
Title: Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation.
The centromere proteins CAL1 and CENP-C are both required for CID assembly in meiosis and normal progression through spermatogenesis.
Title: The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C.
The N-terminal part of Drosophila CENP-C is sufficient to recruit core kinetochore components and acts as the principal linkage between centromere and kinetochore during mitosis.
Title: CENP-C is a structural platform for kinetochore assembly.
Study shows by quantitative fluorescence measurements in living early embryos that functional fluorescent fusion proteins of the Drosophila CENP-A and CENP-C homologs are rapidly incorporated into centromeres during anaphase.
Title: Incorporation of Drosophila CID/CENP-A and CENP-C into centromeres during early embryonic anaphase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kinetochore assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromosome, centromeric region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of centromere complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centromere complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed