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    Wdr92 WD repeat domain 92 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr92provided by FlyBase
    Official Full Name
    WD repeat domain 92provided by FlyBase
    Primary source
    FLYBASE:FBgn0036771
    Locus tag
    Dmel_CG14353
    See related
    AllianceGenome:FB:FBgn0036771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14353; Dmel\CG14353
    Summary
    Predicted to enable protein domain specific binding activity and ubiquitin binding activity. Predicted to be involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Is expressed in chordotonal neurons; chordotonal organ; chordotonal organ precursor cell; and male germline cell. Orthologous to human DNAAF10 (dynein axonemal assembly factor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdr92 in Genome Data Viewer
    Location:
    75A8-75A8; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17908143..17909683)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17901243..17902783)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 74F Neighboring gene prestin Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43174 Neighboring gene long non-coding RNA:CR45393

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
    2. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Glatter T, et al. Mol Syst Biol, 2011 Nov 8. PMID 22068330, Free PMC Article
    3. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    4. Genome-wide measurement of spatial expression in patterning mutants of Drosophila melanogaster. Combs PA, et al. F1000Res, 2017. PMID 28299188, Free PMC Article
    5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat domain 92
    Names
    CG14353-PA
    Wdr92-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17908143..17909683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140768.2 → NP_649025.1  WD repeat domain 92 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNI4, Q9VVM7
      Related
      FBpp0074910
      Conserved Domains (3) summary
      COG2319
      Location:2 → 354
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:111 → 165
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:77 → 366
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVM7 Q9VVM7

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