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    ana2 anastral spindle 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ana2provided by FlyBase
    Official Full Name
    anastral spindle 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0027513
    Locus tag
    Dmel_CG8262
    See related
    AllianceGenome:FB:FBgn0027513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ana-2; Ana2; BcDNA:LD22033; CG8262; Dmel\CG8262; dSTIL; STIL
    Summary
    Involved in asymmetric neuroblast division and microtubule cytoskeleton organization. Located in centriole; centrosome; and ciliary basal body. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ana2 in Genome Data Viewer
    Location:
    44F3-44F3; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8898729..8900211, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4786234..4787716, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dynactin 2, p50 subunit Neighboring gene Secretory 31 Neighboring gene antisense RNA:CR45202 Neighboring gene uncharacterized protein Neighboring gene MRG/MORF4L binding protein Neighboring gene G protein gamma subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Centriole growth is limited by the Cdk/Cyclin-dependent phosphorylation of Ana2/STIL.
      Title: Centriole growth is limited by the Cdk/Cyclin-dependent phosphorylation of Ana2/STIL.
    2. SAPs as a new model to probe the pathway of centriole and centrosome assembly.
      Title: SAPs as a new model to probe the pathway of centriole and centrosome assembly.
    3. A molecular mechanism for the procentriole recruitment of Ana2.
      Title: A molecular mechanism for the procentriole recruitment of Ana2.
    4. Plk4 first phosphorylates the extreme N terminus of Ana2, which is critical for subsequent STAN domain modification. Phosphorylation of the central region then breaks the Plk4-Ana2 interaction. This phosphorylation pattern is important for centriole assembly and integrity.
      Title: An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.
    5. Two-step phosphorylation of Ana2 by Plk4 is required for Ana2 recruitment to the centriole.
      Title: Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.
    6. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.
      Title: The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.
    7. Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2 tetramerization, yielding an Ana2M4-LC88 complex.
      Title: The mechanism of dynein light chain LC8-mediated oligomerization of the Ana2 centriole duplication factor.
    8. these findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during neuroblasts asymmetric division.
      Title: An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.
    9. DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4-dependent manner.
      Title: DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement.
    10. Drosophila Ana2 is a conserved centriole duplication factor.
      Title: Drosophila Ana2 is a conserved centriole duplication factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole-centriole cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ciliary basal body organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anastral spindle 2
    Names
    CG8262-PA
    CG8262-PB
    ana2-PA
    ana2-PB
    anastral spindle phenotype 2
    anastral spindle-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8898729..8900211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299287.1 → NP_001286216.1  anastral spindle 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFU9

    2. NM_136571.3 → NP_610415.1  anastral spindle 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ31
      Related
      FBpp0087766
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFU9 A0A0B4LFU9
    Q9XZ31 Q9XZ31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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