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    spn-D spindle D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318579, updated on 27-Dec-2024

    Summary

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    Official Symbol
    spn-Dprovided by FlyBase
    Official Full Name
    spindle Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003482
    Locus tag
    Dmel_CG31069
    See related
    AllianceGenome:FB:FBgn0003482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE19845; CG31069; Dmel\CG31069; rad51C; Spn-D; SPN-D; spnD; spndD
    Summary
    Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Involved in several processes, including DNA metabolic process; oogenesis; and specification of axis polarity. Is expressed in ovary. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spn-D in Genome Data Viewer
    Location:
    97E6-97E6; 3-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27165716..27167122)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22991438..22992844)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pickpocket 31 Neighboring gene uncharacterized protein Neighboring gene Serrate Neighboring gene long non-coding RNA:CR34006

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple barriers to nonhomologous DNA end joining during meiosis in Drosophila. Joyce EF, et al. Genetics, 2012 Jul. PMID 22542963, Free PMC Article
    2. Studies on crossover-specific mutants and the distribution of crossing over in Drosophila females. Bhagat R, et al. Cytogenet Genome Res, 2004. PMID 15467361
    3. Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females. Mehrotra S, et al. PLoS Genet, 2006 Nov 24. PMID 17166055, Free PMC Article
    4. The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila. Lancaster OM, et al. PLoS Genet, 2010 Oct 28. PMID 21060809, Free PMC Article
    5. Transcriptomic analysis of meiotic genes during the mitosis-to-meiosis transition in Drosophila females. Vallés AM, et al. Genetics, 2024 Oct 7. PMID 39225982

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA strand exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived oocyte fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule organizing center organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte localization involved in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polarity specification of dorsal/ventral axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spindle D
    Names
    CG31069-PA
    spn-D-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27165716..27167122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170321.3 → NP_733200.1  spindle D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ30
      Related
      FBpp0084486
      Conserved Domains (1) summary
      cl21455
      Location:46 → 249
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ30 Q8SZ30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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