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    Pcd pterin-4a-carbinolamine dehydratase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcdprovided by FlyBase
    Official Full Name
    pterin-4a-carbinolamine dehydrataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024841
    Locus tag
    Dmel_CG1963
    See related
    AllianceGenome:FB:FBgn0024841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP07248; CG1963; Dmel\CG1963; pCD; PCD
    Summary
    Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Is expressed in organism. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to several human genes including PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pcd in Genome Data Viewer
    Location:
    99B9-99B9; 3-99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29723163..29724226)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25548885..25549948)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46108 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 40 Neighboring gene uncharacterized protein Neighboring gene Kuzbanian-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the Drosophila melanogaster gene encoding the pterin 4alpha-carbinolamine dehydratase. Seong C, et al. Biochim Biophys Acta, 1998 Oct 14. PMID 9774744
    2. Promoter analysis of the Drosophila melanogaster gene encoding the pterin 4alpha-carbinolamine dehydratase. Park H, et al. Mol Cells, 2001 Oct 31. PMID 11710527
    3. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. Beumer KJ, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979928, Free PMC Article
    4. Quantitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melanogaster. Drnevich JM, et al. Proc Biol Sci, 2004 Nov 7. PMID 15539352, Free PMC Article
    5. The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. Paré A, et al. PLoS One, 2012. PMID 22590528, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pterin-4a-carbinolamine dehydratase
    Names
    CG1963-PA
    Pcd-PA
    NP_477360.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29723163..29724226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058012.4 → NP_477360.2  pterin-4a-carbinolamine dehydratase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6SV03, O76454
      Related
      FBpp0084824
      Conserved Domains (1) summary
      cd00914
      Location:112 → 186
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76454.2 O76454

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