RhoGAP100F Rho GTPase activating protein at 100F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RhoGAP100Fprovided by FlyBase
Official Full Name: Rho GTPase activating protein at 100Fprovided by FlyBase
Primary source: FLYBASE:FBgn0039883
Locus tag: Dmel_CG1976
See related: AllianceGenome:FB:FBgn0039883
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1976; CG1976; Dmel\CG1976; DSyd; dsyd-1; dSyd-1; Dsyd-1; DSyd-1; DSyd1; RHOGAP100F; syd-1; Syd-1; syd1; Syd1
Summary: Predicted to enable GTPase activator activity. Involved in several processes, including cytoskeletal matrix organization at active zone; maintenance of presynaptic active zone structure; and nervous system development. Located in presynaptic active zone. Is active in neuromuscular junction and presynaptic active zone cytoplasmic component. Is expressed in several structures, including adult brain; adult mushroom body; embryonic/larval neuromuscular junction; mushroom body calyx; and organism subdivision. Orthologous to several human genes including SYDE2 (synapse defective Rho GTPase homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100D2-100D3; 3-102 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31812609..31846570)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27638331..27672292)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our live data support a "serial synapse formation" model, where at any time point only 1-2 "synaptogenic" filopodia suppress the synaptic competence of other filopodia through competition for synaptic seeding factors. Loss of the synaptic seeding factors Syd-1 and Liprin-alpha leads to a loss of this suppression, filopodial destabilization, and reduced synapse formation.
Title: Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors.
The Syd-1/liprin-alpha/PP2A pathway stabilizes the active zone in synaptic terminals.
Title: Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.
cooperation between Syd-1 and Nrx-1 seems to orchestrate early assembly processes between pre- and postsynaptic membranes
Title: Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.
DSyd-1 might stall synaptic proteins other than DLiprin-, e.g., adhesion molecules, to regulate postsynaptic maturation in a trans-synaptic manner.
Title: A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISM Inferred from Sequence Model more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	ISM Inferred from Sequence Model more info
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeletal matrix organization at active zone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of presynaptic active zone structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic active zone organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho GTPase activating protein at 100F

Names: CG1976-PB; CG1976-PC; CG1976-PD; CG1976-PE; CG1976-PF; CG1976-PH; CG1976-PI; CG1976-PJ; RhoGAP100F-PB; RhoGAP100F-PC; RhoGAP100F-PD; RhoGAP100F-PE; RhoGAP100F-PF; RhoGAP100F-PH; RhoGAP100F-PI; RhoGAP100F-PJ; synapse defective-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31812609..31846570

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170315.3 → NP_001163786.1 Rho GTPase activating protein at 100F, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163786.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C3KGQ2, E1JJ30, E1JJ31, Q8SWW5, Q9V9S7

Conserved Domains (3) summary

cd00030
Location:804 → 905

C2; C2 domain

cd00992
Location:177 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:946 → 1144

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_001300700.1 → NP_001287629.1 Rho GTPase activating protein at 100F, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287629.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LJ24

Conserved Domains (3) summary

cd00030
Location:804 → 905

C2; C2 domain

cd00992
Location:177 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:946 → 1144

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_001260468.2 → NP_001247397.2 Rho GTPase activating protein at 100F, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247397.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7S3

Conserved Domains (3) summary

cd00030
Location:804 → 905

C2; C2 domain

cd00992
Location:177 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:946 → 1144

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_001170314.2 → NP_001163785.1 Rho GTPase activating protein at 100F, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163785.1

Status: REVIEWED

UniProtKB/TrEMBL

I0C0N0

Conserved Domains (3) summary

cd00030
Location:804 → 905

C2; C2 domain

cd00992
Location:177 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:946 → 1144

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_001260467.2 → NP_001247396.1 Rho GTPase activating protein at 100F, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247396.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7G3

Conserved Domains (3) summary

cd00030
Location:791 → 892

C2; C2 domain

cd00992
Location:166 → 249

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:933 → 1131

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_001260465.1 → NP_001247394.1 Rho GTPase activating protein at 100F, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247394.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6W5

Conserved Domains (3) summary

cd00030
Location:794 → 895

C2; C2 domain

cd00992
Location:166 → 249

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:936 → 1134

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_001260466.1 → NP_001247395.1 Rho GTPase activating protein at 100F, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247395.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K813

Conserved Domains (3) summary

cd00030
Location:793 → 894

C2; C2 domain

cd00992
Location:166 → 249

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:935 → 1133

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
NM_143645.2 → NP_651902.2 Rho GTPase activating protein at 100F, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651902.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V9S7

Conserved Domains (3) summary

cd00030
Location:793 → 894

C2; C2 domain

cd00992
Location:166 → 249

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04379
Location:935 → 1133

RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K6W5		A0A0B4K6W5
A0A0B4K7G3		A0A0B4K7G3
A0A0B4K7S3		A0A0B4K7S3
A0A0B4K813		A0A0B4K813
A0A0B4LJ24		A0A0B4LJ24
Q9V9S7.2		Q9V9S7