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    pxb pxb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pxbprovided by FlyBase
    Official Full Name
    pxbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053207
    Locus tag
    Dmel_CG33207
    See related
    AllianceGenome:FB:FBgn0053207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE16319; CG14873; CG14874; CG33207; CG33207/Pxb; Dmel\CG33207; Pxb
    Summary
    Involved in behavioral response to ethanol; long-term memory; and negative regulation of hemocyte proliferation. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pxb in Genome Data Viewer
    Location:
    89A1-89A2; 3-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15666183..15690513)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11491905..11516235)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43849 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic reprogramming of chromatin accessibility during Drosophila embryo development. Thomas S, et al. Genome Biol, 2011. PMID 21569360, Free PMC Article
    2. Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila. Bhambhani C, et al. PLoS Genet, 2014 Feb. PMID 24516405, Free PMC Article
    3. Activation of wingless targets requires bipartite recognition of DNA by TCF. Chang MV, et al. Curr Biol, 2008 Dec 9. PMID 19062282, Free PMC Article
    4. Requirements of high levels of Hedgehog signaling activity for medial-region cell fate determination in Drosophila legs: identification of pxb, a putative Hedgehog signaling attenuator gene repressed along the anterior-posterior compartment boundary. Inaki M, et al. Mech Dev, 2002 Aug. PMID 12128201
    5. Coordination between stochastic and deterministic specification in the Drosophila visual system. Courgeon M, et al. Science, 2019 Oct 18. PMID 31582524, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In mid-to-late third instar leg discs, high levels of Hedgehog signals repress the transcription of pxb, a newly identified gene encoding a transmembrane protein expressed specifically in the anterior compartment.
      Title: Requirements of high levels of Hedgehog signaling activity for medial-region cell fate determination in Drosophila legs: identification of pxb, a putative Hedgehog signaling attenuator gene repressed along the anterior-posterior compartment boundary.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hemocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pxb
    Names
    CG33207-PB
    CG33207-PC
    baikal
    paxillinB
    pxb-PB
    pxb-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15666183..15690513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275680.1 → NP_001262609.1  pxb, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MY02, Q9VF47

    2. NM_176504.2 → NP_788681.1  pxb, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788681.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MY02, Q9VF47
      Related
      FBpp0082616
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MY02 Q8MY02
    Q8SXK4 Q8SXK4

    Gene LinkOut

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