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    msl-3 male-specific lethal 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38779, updated on 9-Dec-2024

    Summary

    Official Symbol
    msl-3provided by FlyBase
    Official Full Name
    male-specific lethal 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0002775
    Locus tag
    Dmel_CG8631
    See related
    AllianceGenome:FB:FBgn0002775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8631; Dmel\CG8631; DmMsl-3; mle(3)132; mle3; mls3; msl; MSL; Msl 1-3; MSL-3; msl3; Msl3; MSL3; MSL3_DROME
    Summary
    Enables several functions, including histone reader activity; lncRNA binding activity; and methylated histone binding activity. Involved in dosage compensation by hyperactivation of X chromosome; oocyte development; and regulation of hemocyte proliferation. Located in chromocenter and chromosome. Part of MSL complex and X chromosome located dosage compensation complex, transcription activating. Is expressed in organism. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to several human genes including MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See msl-3 in Genome Data Viewer
    Location:
    65E4-65E4; 3-19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7123213..7125533, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7116313..7118633, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 65Eb Neighboring gene Cuticular protein 65Ec Neighboring gene formin 3 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene Acyl-CoA binding protein 4 Neighboring gene Acyl-CoA binding protein 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lncRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MSL complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MSL complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of X chromosome located dosage compensation complex, transcription activating IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of X chromosome located dosage compensation complex, transcription activating NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    male-specific lethal 3
    Names
    CG8631-PA
    gene 2
    male sex lethal 3
    male sex lethal-3
    male specifc lethal
    male specific lethal 3
    males specific lethal 3
    msl-3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7123213..7125533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079227.3NP_523951.1  male-specific lethal 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8BP72, A8BP74, A8BP87, A8BP92, A8IL14, A8IL17, A8IL22, A8IL25, A8IL30, A8IL33, A8IL37, A8IL41, A8IL46, P50536, Q8IQ74, Q9VS18
      UniProtKB/TrEMBL
      I1V4X9
      Related
      FBpp0076635
      Conserved Domains (1) summary
      pfam05712
      Location:196486
      MRG; MRG