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    mon2 monensin sensitivity 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mon2provided by FlyBase
    Official Full Name
    monensin sensitivity 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031985
    Locus tag
    Dmel_CG8683
    See related
    AllianceGenome:FB:FBgn0031985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14276; CG31756; CG8683; Dmel\CG8683; Mon2; noan
    Summary
    Enables cytoskeletal regulatory protein binding activity. Involved in actin cytoskeleton organization and pole plasm protein localization. Located in Golgi apparatus and endosome. Is expressed in adult head. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mon2 in Genome Data Viewer
    Location:
    28E6-28E7; 2-30 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8116965..8124010, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8116965..8124010, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Macroglobulin complement-related Neighboring gene antisense RNA:CR45257 Neighboring gene Basigin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oskar-induced endocytic activation and actin remodeling for anchorage of the Drosophila germ plasm. Tanaka T, et al. Bioarchitecture, 2011 May. PMID 21922042, Free PMC Article
    2. Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. Tanaka T, et al. Development, 2011 Jun. PMID 21610029
    3. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article
    4. Nociceptor-Enriched Genes Required for Normal Thermal Nociception. Honjo K, et al. Cell Rep, 2016 Jul 12. PMID 27346357, Free PMC Article
    5. SUMO-Enriched Proteome for Drosophila Innate Immune Response. Handu M, et al. G3 (Bethesda), 2015 Aug 18. PMID 26290570, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. report that a Golgi-endosomal protein, Mon2, acts downstream of Osk to remodel cortical actin and to anchor the pole plasm
      Title: Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytoskeletal regulatory protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monensin sensitivity 2
    Names
    CG8683-PB
    CG8683-PC
    mon2-PB
    mon2-PC
    no anchor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8116965..8124010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038795.3 → NP_001033884.2  monensin sensitivity 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033884.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WHI7, Q961N6, Q9VLT1, Q9VLT2
      UniProtKB/TrEMBL
      X2J564
      Conserved Domains (4) summary
      pfam09324
      Location:827 → 909
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:213 → 380
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:912 → 1665
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:13 → 184
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    2. NM_001298810.1 → NP_001285739.1  monensin sensitivity 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285739.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WHI7, Q961N6, Q9VLT1, Q9VLT2
      UniProtKB/TrEMBL
      X2J564
      Conserved Domains (4) summary
      pfam09324
      Location:827 → 909
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:213 → 380
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:912 → 1665
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:13 → 184
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLT1.4 Q9VLT1
    X2J564 X2J564

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