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    l(1)G0020 lethal (1) G0020 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(1)G0020provided by FlyBase
    Official Full Name
    lethal (1) G0020provided by FlyBase
    Primary source
    FLYBASE:FBgn0027330
    Locus tag
    Dmel_CG1994
    See related
    AllianceGenome:FB:FBgn0027330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1994; Dmel\CG1994; NAT10; p110
    Summary
    Predicted to enable rRNA cytidine N-acetyltransferase activity and tRNA binding activity. Predicted to be involved in rRNA acetylation involved in maturation of SSU-rRNA. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in adult head. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(1)G0020 in Genome Data Viewer
    Location:
    8A2-8A3; 1-24 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8716713..8720277, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8610746..8614310, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44507 Neighboring gene long non-coding RNA:CR44508 Neighboring gene Hexosaminidase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43297

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development. Zhou J, et al. PLoS Genet, 2019 Sep. PMID 31553718, Free PMC Article
    2. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
    3. Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells. Onishi R, et al. Sci Adv, 2020 Dec. PMID 33310860, Free PMC Article
    4. Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster. Berlandi J, et al. Neuro Oncol, 2019 May 6. PMID 30715493, Free PMC Article
    5. Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster. Macdonald SJ, et al. Genetics, 2007 Jun. PMID 17435224, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA cytidine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble cytosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lethal (1) G0020
    Names
    CG1994-PA
    CG1994-PB
    l(1)G0020-PA
    l(1)G0020-PB
    NP_001285025.1
    NP_572503.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8716713..8720277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132275.2 → NP_572503.1  lethal (1) G0020, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NR51, Q9W3C1
      UniProtKB/TrEMBL
      H0RNM5
      Related
      FBpp0071217
      Conserved Domains (5) summary
      COG1444
      Location:21 → 882
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
      pfam05127
      Location:276 → 461
      Helicase_RecD; Helicase
      pfam08351
      Location:104 → 198
      DUF1726; Domain of unknown function (DUF1726)
      pfam13718
      Location:501 → 726
      GNAT_acetyltr_2; GNAT acetyltransferase 2
      pfam13725
      Location:744 → 863
      tRNA_bind_2; Possible tRNA binding domain

    2. NM_001298096.1 → NP_001285025.1  lethal (1) G0020, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD07
      Conserved Domains (5) summary
      COG1444
      Location:21 → 882
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
      pfam05127
      Location:276 → 461
      Helicase_RecD; Helicase
      pfam08351
      Location:104 → 198
      DUF1726; Domain of unknown function (DUF1726)
      pfam13718
      Location:501 → 726
      GNAT_acetyltr_2; GNAT acetyltransferase 2
      pfam13725
      Location:744 → 863
      tRNA_bind_2; Possible tRNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3C1.2 Q9W3C1
    X2JD07 X2JD07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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