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    CG30344 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30344provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050344
    Locus tag
    Dmel_CG30344
    See related
    AllianceGenome:FB:FBgn0050344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8054; Dmel\CG30344; met; MET
    Summary
    Predicted to enable transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be active in membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval garland cell; and garland cell primordium. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30344 in Genome Data Viewer
    Location:
    45A12-45A13; 2-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9145260..9148512)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5032765..5036017)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene shrub Neighboring gene pre-mRNA processing factor 38 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster. Chahine S, et al. J Exp Biol, 2012 Aug 1. PMID 22786636
    2. Effects of genetic knock-down of organic anion transporter genes on secretion of fluorescent organic ions by Malpighian tubules of Drosophila melanogaster. Chahine S, et al. Arch Insect Biochem Physiol, 2012 Dec. PMID 22972675
    3. Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules of Drosophila melanogaster larvae. Chahine S, et al. Arch Insect Biochem Physiol, 2010 Mar. PMID 20077573
    4. Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster. Chahine S, et al. J Insect Physiol, 2009 Oct. PMID 19545574
    5. Benzene induced resistance in exposed Drosophila melanogaster: Outcome of improved detoxification and gene modulation. Sharma D, et al. Chemosphere, 2018 Jun. PMID 29524815

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in renal tubular secretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30344-PA
    multi drug efflux transporter
    multidrug efflux transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9145260..9148512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165655.3 → NP_724759.1  uncharacterized protein Dmel_CG30344 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961H2
      Related
      FBpp0087664
      Conserved Domains (2) summary
      cd06174
      Location:113 → 490
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:128 → 448
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961H2 Q961H2

    Gene LinkOut

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