Wnt10 Wnt oncogene analog 10 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wnt10provided by FlyBase
Official Full Name: Wnt oncogene analog 10provided by FlyBase
Primary source: FLYBASE:FBgn0031903
Locus tag: Dmel_CG4971
See related: AllianceGenome:FB:FBgn0031903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4971; D-Wnt-10; Dm DWnt10; Dmel\CG4971; Dwnt-10; DWnt-10; Dwnt10; DWnt10; wnt10
Summary: Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in canonical Wnt signaling pathway; cell fate commitment; and neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including foregut primordium; ganglia; hindgut proper primordium; midgut primordium; and somatic mesoderm. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to several human genes including WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7363379..7377528)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7363379..7377528)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain.
Title: DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info