U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Plap Phospholipase A2 activator protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43978, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Plapprovided by FlyBase
    Official Full Name
    Phospholipase A2 activator proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024314
    Locus tag
    Dmel_CG5105
    See related
    AllianceGenome:FB:FBgn0024314
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5105; Dmel\CG5105; dmPLAP; dPLAP; Plaa; plap; UFD3
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; ganglia; and larval nervous system. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Plap in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1167172..1170365, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1167172..1170365, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Integrator 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene charon Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. Avery MA, et al. J Cell Biol, 2009 Feb 23. PMID 19237597, Free PMC Article
    2. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article
    3. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    4. Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism. Brown RP, et al. BMC Genomics, 2005 Aug 17. PMID 16107220, Free PMC Article
    5. FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction. Gupta A, et al. Elife, 2020 Jun 11. PMID 32525804, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phospholipase A2 activator protein
    Names
    CG5105-PA
    CG5105-PB
    CG5105-PC
    Plap-PA
    Plap-PB
    Plap-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1167172..1170365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298628.1 → NP_001285557.1  phospholipase A2 activator protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285557.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GUB1, Q9VPY2
      Conserved Domains (5) summary
      COG2319
      Location:4 → 266
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 305
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:531 → 781
      PUL; PUL domain
      pfam09070
      Location:353 → 462
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:23 → 64
      7WD40; WD40 repeat [structural motif]

    2. NM_079927.3 → NP_524666.2  phospholipase A2 activator protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524666.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GUB1, Q9VPY2
      Related
      FBpp0077645
      Conserved Domains (5) summary
      COG2319
      Location:4 → 266
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 305
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:531 → 781
      PUL; PUL domain
      pfam09070
      Location:353 → 462
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:23 → 64
      7WD40; WD40 repeat [structural motif]

    3. NM_001258900.2 → NP_001245829.1  phospholipase A2 activator protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GUB1, Q9VPY2
      Conserved Domains (5) summary
      COG2319
      Location:4 → 266
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 305
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:531 → 781
      PUL; PUL domain
      pfam09070
      Location:353 → 462
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:23 → 64
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3YNF8 Q3YNF8
    Q9GUB1 Q9GUB1
    Q9VPY2 Q9VPY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools