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    Hrd3 HMG-coA reductase degradation 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hrd3provided by FlyBase
    Official Full Name
    HMG-coA reductase degradation 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028475
    Locus tag
    Dmel_CG10221
    See related
    AllianceGenome:FB:FBgn0028475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD23587; CG10221; Dmel\CG10221; hrd3; HRD3
    Summary
    Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hrd3 in Genome Data Viewer
    Location:
    95B1-95B1; 3-80 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23754623..23758557, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19580345..19584279, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene HMG Coenzyme A reductase Neighboring gene Ran binding protein 3 Neighboring gene Regulatory particle triple-A ATPase 5 Neighboring gene Protein tyrosine phosphatase, mitochondrial 1 Neighboring gene Succinate dehydrogenase, subunit D Neighboring gene undicht

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity. You S, et al. Genes Cells, 2018 Sep. PMID 30043468
    2. Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes. Napoli B, et al. Front Neurosci, 2019. PMID 31803000, Free PMC Article
    3. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
    4. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. Lindström R, et al. PLoS One, 2016. PMID 26975047, Free PMC Article
    5. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HMG-coA reductase degradation 3
    Names
    CG10221-PA
    CG10221-PB
    Hrd3-PA
    Hrd3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23754623..23758557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275953.1 → NP_001262882.1  HMG-coA reductase degradation 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V415
      Conserved Domains (3) summary
      smart00671
      Location:407 → 441
      SEL1; Sel1-like repeats
      COG0790
      Location:334 → 649
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:353 → 382
      SLR; SLR repeat [structural motif]

    2. NM_142922.3 → NP_651179.1  HMG-coA reductase degradation 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V415
      Related
      FBpp0083858
      Conserved Domains (3) summary
      smart00671
      Location:407 → 441
      SEL1; Sel1-like repeats
      COG0790
      Location:334 → 649
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:353 → 382
      SLR; SLR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V415 Q9V415

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