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    CG1998 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1998provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030485
    Locus tag
    Dmel_CG1998
    See related
    AllianceGenome:FB:FBgn0030485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1998
    Summary
    Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human FAXDC2 (fatty acid hydroxylase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1998 in Genome Data Viewer
    Location:
    11F4-11F4; 1-43 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13409369..13413074, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13303402..13307107, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase T4 Neighboring gene SET domain containing 2 Neighboring gene Neuropilin and tolloid-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila lacks C20 and C22 PUFAs. Shen LR, et al. J Lipid Res, 2010 Oct. PMID 20656917, Free PMC Article
    2. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    3. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article
    4. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Behm-Ansmant I, et al. Genes Dev, 2006 Jul 15. PMID 16815998, Free PMC Article
    5. Quantitative trait loci for cuticular hydrocarbons associated with sexual isolation between Drosophila simulans and D. sechellia. Gleason JM, et al. Genetics, 2005 Dec. PMID 16143629, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1998-PA
    CG1998-PB
    CG1998-PC
    NP_001162739.1
    NP_001285210.1
    NP_572887.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13409369..13413074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132659.3 → NP_572887.1  uncharacterized protein Dmel_CG1998, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYD2
      Related
      FBpp0073618
      Conserved Domains (2) summary
      COG3000
      Location:245 → 374
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:250 → 374
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    2. NM_001298281.1 → NP_001285210.1  uncharacterized protein Dmel_CG1998, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYD2
      Conserved Domains (2) summary
      COG3000
      Location:245 → 374
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:250 → 374
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    3. NM_001169268.2 → NP_001162739.1  uncharacterized protein Dmel_CG1998, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162739.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJN0
      Conserved Domains (2) summary
      COG3000
      Location:137 → 266
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:142 → 266
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJN0 E1JJN0
    Q9VYD2 Q9VYD2

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