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    Smu1 Smu1 spliceosomal factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smu1provided by FlyBase
    Official Full Name
    Smu1 spliceosomal factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038666
    Locus tag
    Dmel_CG5451
    See related
    AllianceGenome:FB:FBgn0038666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5451; Dmel\CG5451; dsmu1
    Summary
    Involved in neuromuscular junction development; neuromuscular synaptic transmission; and terminal button organization. Located in cytoplasm and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smu1 in Genome Data Viewer
    Location:
    91E1-91E2; 3-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18978980..18981324, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14804702..14807046, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small ribonucleoprotein particle U1 subunit C Neighboring gene eucalyptus Neighboring gene deoxyribonucleoside kinase Neighboring gene GUK-holder

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag. Beck ES, et al. J Neurosci, 2012 May 16. PMID 22593074, Free PMC Article
    2. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article
    3. Alternative splicing in Drosophila neuronal development. Mohr C, et al. J Neurogenet, 2014 Sep-Dec. PMID 24957133
    4. The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance. Ariyapala IS, et al. Genetics, 2022 Sep 30. PMID 35762963, Free PMC Article
    5. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Cheng LW, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157870, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Smu1 spliceosomal factor
    Names
    CG5451-PA
    CG5451-PB
    CG5451-PC
    SMU1 ortholog
    Smu1-PA
    Smu1-PB
    Smu1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18978980..18981324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260260.1 → NP_001247189.1  Smu1 spliceosomal factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P6, Q9VE18
      Conserved Domains (4) summary
      smart00668
      Location:40 → 90
      CTLH; C-terminal to LisH motif
      cd00200
      Location:214 → 508
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:218 → 256
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:7 → 36
      LisH_TPL; LisH-like dimerisation domain

    2. NM_001260261.1 → NP_001247190.1  Smu1 spliceosomal factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P6, Q9VE18
      Conserved Domains (4) summary
      smart00668
      Location:40 → 90
      CTLH; C-terminal to LisH motif
      cd00200
      Location:214 → 508
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:218 → 256
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:7 → 36
      LisH_TPL; LisH-like dimerisation domain

    3. NM_142509.5 → NP_650766.1  Smu1 spliceosomal factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P6, Q9VE18
      Related
      FBpp0083135
      Conserved Domains (4) summary
      smart00668
      Location:40 → 90
      CTLH; C-terminal to LisH motif
      cd00200
      Location:214 → 508
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:218 → 256
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:7 → 36
      LisH_TPL; LisH-like dimerisation domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE18 Q9VE18

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