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    Art1 Arginine methyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art1provided by FlyBase
    Official Full Name
    Arginine methyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037834
    Locus tag
    Dmel_CG6554
    See related
    AllianceGenome:FB:FBgn0037834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ART1; CG6554; Dart; dart1; Dart1; DART1; Dmel\CG6554; PRMT1
    Summary
    Enables nuclear receptor corepressor activity and protein-arginine N-methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in adult heart; organism; and ovary. Orthologous to several human genes including PRMT8 (protein arginine methyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Art1 in Genome Data Viewer
    Location:
    86C6-86C6; 3-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10786481..10788226, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6612203..6613948, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene RNA-binding protein 1 Neighboring gene Minichromosome maintenance 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple Arginine Residues Are Methylated in Drosophila Mre11 and Required for Survival Following Ionizing Radiation. Yuan Q, et al. G3 (Bethesda), 2018 May 31. PMID 29695495, Free PMC Article
    2. Long noncoding RNA-dependent methylation of nonhistone proteins. Jantrapirom S, et al. Wiley Interdiscip Rev RNA, 2021 Nov. PMID 33913612
    3. Arginine Methylation Initiates BMP-Induced Smad Signaling. Xu J, et al. Mol Cell, 2013 Jul 11. PMID 23747011, Free PMC Article
    4. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Kimura S, et al. Biochem Biophys Res Commun, 2008 Jul 11. PMID 18468516
    5. Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo. Scaramuzzino C, et al. PLoS One, 2013. PMID 23620769, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that knockdown of Dart1 leds to a reduction in methylation of hFUS P525L and aggravated the neurodegenerative phenotype in transgenic flies
      Title: Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.
    2. wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation.
      Title: Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
    3. These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly.
      Title: Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor.
    4. Identification of DART1 and DART4, protein arginine methyltransferases, that are expressed in various Drosophila developmental stages
      Title: Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H4R3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor corepressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine omega-N monomethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine omega-N monomethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arginine methyltransferase 1
    Names
    Arg methyltransferase 1
    Art1-PA
    CG6554-PA
    NP_650017.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10786481..10788226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141760.4 → NP_650017.1  arginine methyltransferase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0MJ37, Q9VGW7
      Related
      FBpp0081780
      Conserved Domains (1) summary
      cd02440
      Location:94 → 194
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGW7 Q9VGW7

    Gene LinkOut

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