mam mastermind [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mamprovided by FlyBase
Official Full Name: mastermindprovided by FlyBase
Primary source: FLYBASE:FBgn0002643
Locus tag: Dmel_CG8118
See related: AllianceGenome:FB:FBgn0002643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8118; Dm0064; dMam; DMam; Dmel\CG8118; l(2)03505; l(2)04615; Mam; MAM; mam(CAG)[[7]]; MamH; N-2G; SR2-4
Summary: Enables transcription coactivator activity. Involved in several processes, including apposition of dorsal and ventral imaginal disc-derived wing surfaces; cell fate determination; and lateral inhibition. Located in nucleus and polytene chromosome puff. Part of CSL-Notch-Mastermind transcription factor complex. Is expressed in several structures, including epithelium; ganglia; germ layer; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 50C23-50D3; 2-68 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13991203..14060356)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9878708..9947861)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind.
Title: Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind.
Characterization of a new mastermind allele identified from somatic mosaic screen.
Title: Characterization of a new mastermind allele identified from somatic mosaic screen.
A transcriptomic analysis identifies mastermind as a candidate gene involved in ovarian stem cell niche ageing.
Title: mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary.
Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
Title: Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
Results identify Mastermind, the Notch pathway transcriptional co-activator, as a rare dose-dependent modifier of aberrant follicle stem cell expansion induced by excess Hedgehog.
Title: Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind.
The findings in this study suggest Mam is not always necessary and sufficient for co-activation of binary Su(H)/NICD complexes on SPS elements.
Title: Promoter-specific co-activation by Drosophila mastermind.
Mam protein might associate during the asymmetric specification of cell fates and the N-terminal region of the protein plays a role in this process.
Title: Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.
an alternative product of the mastermind locus that represses notch signalling
Title: A naturally occurring alternative product of the mastermind locus that represses notch signalling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi15f09.x1 (e-PCR)
- UniSTS:196884

Dm0777 (e-PCR)
- UniSTS:76901

Dm0339 (e-PCR)
- UniSTS:51706

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CSL-Notch-Mastermind transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of CSL-Notch-Mastermind transcription factor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed