wg wingless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wgprovided by FlyBase
Official Full Name: winglessprovided by FlyBase
Primary source: FLYBASE:FBgn0284084
Locus tag: Dmel_CG4889
See related: AllianceGenome:FB:FBgn0284084
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Br; CG4889; D.int-1; Dint-1; Dm Wg; Dm-1; Dmel\CG4889; DWint-1; dWnt; Dwnt-1; DWnt-1; fg; Gla; I; int-1; l(2)02657; l(2)rO727; l(2)SH1281; l(2)SH2 1281; l(2)wg; Sp; spd; Wg; WG; wgl; wnt; Wnt; WNT; Wnt-1; wnt1; Wnt1
Summary: Enables several functions, including glycosaminoglycan binding activity; heparan sulfate proteoglycan binding activity; and signaling receptor binding activity. Involved in several processes, including Malpighian tubule development; open tracheal system development; and regionalization. Located in several cellular components, including membrane raft; multivesicular body; and terminal bouton. Colocalizes with early endosome and late endosome. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; gut section; larval imaginal tissue; and somatic precursor cell. Used to study obesity. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27F1-27F1; 2-26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7307159..7316265)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7307159..7316265)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dissociation of Drosophila Evi-Wg Complex Occurs Post Apical Internalization in the Maturing Acidic Endosomes.
Title: Dissociation of Drosophila Evi-Wg Complex Occurs Post Apical Internalization in the Maturing Acidic Endosomes.
Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Title: Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
Title: Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes.
Title: Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes.
Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless.
Title: Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless.
Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling.
Title: Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling.
Extracellular spreading of Wingless is required for Drosophila oogenesis.
Title: Extracellular spreading of Wingless is required for Drosophila oogenesis.
Wing patterning in faster developing Drosophila is associated with high ecdysone titer and wingless expression.
Title: Wing patterning in faster developing Drosophila is associated with high ecdysone titer and wingless expression.
A unified mechanism for the control of Drosophila wing growth by the morphogens Decapentaplegic and Wingless.
Title: A unified mechanism for the control of Drosophila wing growth by the morphogens Decapentaplegic and Wingless.
Activity-dependent endocytosis of Wingless regulates synaptic plasticity in the Drosophila visual system.
Title: Activity-dependent endocytosis of Wingless regulates synaptic plasticity in the Drosophila visual system.

Submit: New GeneRIF Correction See all GeneRIFs (200)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IDA Inferred from Direct Assay more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparan sulfate proteoglycan binding	IPI Inferred from Physical Interaction more info	PubMed
enables morphogen activity	IDA Inferred from Direct Assay more info	PubMed
enables morphogen activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IGI Inferred from Genetic Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Malpighian tubule tip cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin-based larval cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell type specification, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc anterior/posterior pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in genital disc sexually dimorphic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histoblast morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in labial disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proboscis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: wingless

Names: CG4889-PA; Wg; Wnt-1; bristled; complementation group I; flag; glazed; lethal (2) SH1281; spade; sternopleural; wg-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

7307159..7316265

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078778.5 → NP_523502.1 wingless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523502.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P09615, Q27768, Q27769, Q8IPI1, Q8MQP9, Q9VM27

UniProtKB/TrEMBL

I1WYH9

Related

FBpp0079060

Conserved Domains (1) summary

cd19333
Location:64 → 468

Wnt_Wnt1; Wnt domain found in proto-oncogene Wnt-1 and similar proteins