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    CG4733 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4733provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038744
    Locus tag
    Dmel_CG4733
    See related
    AllianceGenome:FB:FBgn0038744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    B''; Dmel\CG4733; dPP2A-PR72; dPR72; PP2A like; PP2A-B''; PR-72; pr72; PR72
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Orthologous to several human genes including PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4733 in Genome Data Viewer
    Location:
    92B4-92B6; 3-67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19890689..19898738)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15716411..15724460)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Apoptotic signal-regulating kinase 1 Neighboring gene neither inactivation nor afterpotential E Neighboring gene Caseinolytic protease chaperone subunit Neighboring gene Rho GTPase activating protein at 92B Neighboring gene long non-coding RNA:CR45047 Neighboring gene Surfeit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis. Wang X, et al. J Mol Cell Biol, 2017 Apr 1. PMID 27702760
    2. A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A. Liu W, et al. Mol Cell Proteomics, 2007 Feb. PMID 17121811
    3. The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. Brownlee CW, et al. J Cell Biol, 2011 Oct 17. PMID 21987638, Free PMC Article
    4. Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Bielinski VA, et al. Exp Cell Res, 2007 Aug 15. PMID 17570358, Free PMC Article
    5. PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos. Wang P, et al. PLoS Genet, 2011 Aug. PMID 21852958, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4733-PB
    CG4733-PC
    CG4733-PD
    CG4733-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19890689..19898738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260269.2 → NP_001247198.1  uncharacterized protein Dmel_CG4733, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FT13, Q0IGX7, Q9I7J1
      Conserved Domains (1) summary
      pfam13499
      Location:690 → 791
      EF-hand_7; EF-hand domain pair

    2. NM_001300483.1 → NP_001287412.1  uncharacterized protein Dmel_CG4733, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHF0, Q0IGX7
      Conserved Domains (1) summary
      pfam13499
      Location:684 → 785
      EF-hand_7; EF-hand domain pair

    3. NM_001260268.1 → NP_001247197.1  uncharacterized protein Dmel_CG4733, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FT13, Q0IGX7, Q9I7J1
      Conserved Domains (1) summary
      pfam13499
      Location:690 → 791
      EF-hand_7; EF-hand domain pair

    4. NM_142585.3 → NP_650842.2  uncharacterized protein Dmel_CG4733, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650842.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FT13, Q0IGX7, Q9I7J1
      Conserved Domains (1) summary
      pfam13499
      Location:690 → 791
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHF0 A0A0B4LHF0
    Q9I7J1 Q9I7J1

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