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    CG13282 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13282provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032612
    Locus tag
    Dmel_CG13282
    See related
    AllianceGenome:FB:FBgn0032612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13282
    Summary
    Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13282 in Genome Data Viewer
    Location:
    36B2-36B2; 2-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16832065..16834502, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16832065..16834502, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene midway Neighboring gene Chromosome segregation 1 Neighboring gene Aspartyl-tRNA synthetase, mitochondrial Neighboring gene Neprilysin-like 9 Neighboring gene Sarcolamban B Neighboring gene Sarcolamban A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Magny EG, et al. Science, 2013 Sep 6. PMID 23970561
    2. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13282-PA
    CG13282-PB
    NP_001260521.1
    NP_609814.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16832065..16834502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273592.1 → NP_001260521.1  uncharacterized protein Dmel_CG13282, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V646, Q9VJH1
      Conserved Domains (2) summary
      cd00707
      Location:75 → 347
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:67 → 351
      Lipase; Lipase

    2. NM_135970.2 → NP_609814.1  uncharacterized protein Dmel_CG13282, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V646, Q9VJH1
      Related
      FBpp0080483
      Conserved Domains (2) summary
      cd00707
      Location:75 → 347
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:67 → 351
      Lipase; Lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJH1 Q9VJH1

    Gene LinkOut

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