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    Blos4 Biogenesis of lysosome-related organelles complex 1, subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Blos4provided by FlyBase
    Official Full Name
    Biogenesis of lysosome-related organelles complex 1, subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0036105
    Locus tag
    Dmel_CG14149
    See related
    AllianceGenome:FB:FBgn0036105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    blos4; CG14149; Dm Blos4; Dmel\CG14149; NP_648414
    Summary
    Involved in eye pigment granule organization. Predicted to be part of BLOC-1 complex. Is expressed in organism. Orthologous to several human genes including BLOC1S4 (biogenesis of lysosomal organelles complex 1 subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Blos4 in Genome Data Viewer
    Location:
    67F1-67F1; 3-33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10879085..10880188)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10872185..10873288)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene tonalli Neighboring gene long non-coding RNA:CR45169 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene galla-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. Mullin AP, et al. J Neurosci, 2015 Jan 7. PMID 25568125, Free PMC Article
    2. A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1). Rodriguez-Fernandez IA, et al. J Inherit Metab Dis, 2009 Apr. PMID 19083121, Free PMC Article
    3. Early origin of genes encoding subunits of biogenesis of lysosome-related organelles complex-1, -2 and -3. Cheli VT, et al. Traffic, 2010 May. PMID 20102546
    4. The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5). Falcón-Pérez JM, et al. Traffic, 2007 Feb. PMID 17156100
    5. Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Cheli VT, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015953, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eye pigment granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biogenesis of lysosome-related organelles complex 1, subunit 4
    Names
    BLOC-1 subunit 4
    Blos4-PA
    Blos4-PB
    CG14149-PA
    CG14149-PB
    cappuccino

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10879085..10880188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140157.3 → NP_648414.1  biogenesis of lysosome-related organelles complex 1, subunit 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTC2
      UniProtKB/TrEMBL
      M9PET7
      Related
      FBpp0075998

    2. NM_001274760.1 → NP_001261689.1  biogenesis of lysosome-related organelles complex 1, subunit 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261689.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTC2
      UniProtKB/TrEMBL
      M9PET7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PET7 M9PET7
    Q9VTC2.1 Q9VTC2

    Gene LinkOut

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