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    Orp8 Oxysterol-binding protein-related protein 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orp8provided by FlyBase
    Official Full Name
    Oxysterol-binding protein-related protein 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0261550
    Locus tag
    Dmel_CG42668
    See related
    AllianceGenome:FB:FBgn0261550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15684; CG42668; CG5077; Dmel\CG42668
    Old locus tag
    Dmel_CG15684; Dmel_CG5077
    Summary
    Predicted to enable cholesterol binding activity and phospholipid transporter activity. Predicted to be involved in phospholipid transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and membrane. Is expressed in several structures, including adult fat body; adult head; embryonic/larval midgut primordium; germline cell; and gut section. Orthologous to human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Orp8 in Genome Data Viewer
    Location:
    92E2-92E2; 3-68 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20309344..20324196)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16135066..16149918)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45800 Neighboring gene uncharacterized protein Neighboring gene Sirtuin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia. Byrne DJ, et al. Acta Neuropathol Commun, 2022 Mar 28. PMID 35346366, Free PMC Article
    2. Case studies of ends-out gene targeting in Drosophila. Chen H, et al. Genesis, 2009 May. PMID 19298016
    3. OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. Ma Z, et al. Development, 2010 Nov. PMID 20943709
    4. Sex-specific pharmacokinetic response to phytoestrogens in Drosophila melanogaster. Sadova N, et al. Biomed Pharmacother, 2024 Jun. PMID 38663102
    5. GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. Okumura T, et al. Gene Expr Patterns, 2007 Jan. PMID 16914392

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Oxysterol-binding protein-related protein 8
    Names
    CG42668-PD
    CG42668-PE
    CG42668-PF
    CG42668-PG
    CG42668-PH
    CG42668-PK
    CG42668-PL
    CG42668-PM
    CG42668-PN
    Orp8-PD
    Orp8-PE
    Orp8-PF
    Orp8-PG
    Orp8-PH
    Orp8-PK
    Orp8-PL
    Orp8-PM
    Orp8-PN
    oxysterol-binding protein-related protein 8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20309344..20324196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202322.2 → NP_001189251.1  Oxysterol-binding protein-related protein 8, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDG2, C6TPA8
      Conserved Domains (4) summary
      cd00890
      Location:815 → 909
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cd13286
      Location:197 → 327
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:204 → 322
      PH; PH domain
      pfam01237
      Location:437 → 762
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001202321.3 → NP_001189250.2  Oxysterol-binding protein-related protein 8, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189250.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCZ0, C6TPA8
      Conserved Domains (4) summary
      cd00890
      Location:849 → 943
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cd13286
      Location:231 → 361
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:238 → 356
      PH; PH domain
      pfam01237
      Location:471 → 796
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001202323.2 → NP_001189252.1  Oxysterol-binding protein-related protein 8, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDG2, C6TPA8
      Conserved Domains (4) summary
      cd00890
      Location:815 → 909
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cd13286
      Location:197 → 327
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:204 → 322
      PH; PH domain
      pfam01237
      Location:437 → 762
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_001144614.2 → NP_001138086.1  Oxysterol-binding protein-related protein 8, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0M9, C6TPA8
      Conserved Domains (3) summary
      cd13286
      Location:57 → 187
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:64 → 182
      PH; PH domain
      pfam01237
      Location:438 → 763
      Oxysterol_BP; Oxysterol-binding protein

    5. NM_142621.6 → NP_650878.4  Oxysterol-binding protein-related protein 8, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650878.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPA8, Q9I7I8
      Conserved Domains (3) summary
      cd13286
      Location:57 → 187
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:64 → 182
      PH; PH domain
      pfam01237
      Location:297 → 622
      Oxysterol_BP; Oxysterol-binding protein

    6. NM_169892.5 → NP_732499.4  Oxysterol-binding protein-related protein 8, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732499.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP47, Q8IN56, Q961G0
      Conserved Domains (3) summary
      cd13286
      Location:57 → 187
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:64 → 182
      PH; PH domain
      pfam01237
      Location:288 → 604
      Oxysterol_BP; Oxysterol-binding protein

    7. NM_169893.4 → NP_732500.5  Oxysterol-binding protein-related protein 8, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732500.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPA8, Q7KSB3
      Conserved Domains (3) summary
      cd13286
      Location:58 → 188
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:65 → 183
      PH; PH domain
      pfam01237
      Location:439 → 764
      Oxysterol_BP; Oxysterol-binding protein

    8. NM_001202320.2 → NP_001189249.2  Oxysterol-binding protein-related protein 8, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189249.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDD8, C6TPA8
      Conserved Domains (3) summary
      cd13286
      Location:58 → 188
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:65 → 183
      PH; PH domain
      pfam01237
      Location:298 → 623
      Oxysterol_BP; Oxysterol-binding protein

    9. NM_169894.4 → NP_732501.1  Oxysterol-binding protein-related protein 8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NP7, Q8IN55
      Related
      FBpp0291806
      Conserved Domains (1) summary
      pfam01237
      Location:106 → 431
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCZ0 A0A0B4JCZ0
    A0A0B4JDD8 A0A0B4JDD8
    A0A0B4JDG2 A0A0B4JDG2
    B7Z0M9 B7Z0M9
    Q7KSB3 Q7KSB3
    Q8IN55 Q8IN55
    Q8IN56 Q8IN56
    Q9I7I8 Q9I7I8

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