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    fwd four wheel drive [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fwdprovided by FlyBase
    Official Full Name
    four wheel driveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004373
    Locus tag
    Dmel_CG7004
    See related
    AllianceGenome:FB:FBgn0004373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.259; CG7004; Dmel\CG7004; Fwd; PI4K; PI4K3B; PI4KIIIbeta
    Summary
    Predicted to enable 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; determination of adult lifespan; and spermatogenesis. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fwd in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (305393..319884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (305393..319884, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene tiny tim 2 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene deadbeat Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Brill JA, et al. Development, 2000 Sep. PMID 10934029
    2. Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth. Dason JS, et al. J Cell Sci, 2009 Nov 15. PMID 19861494
    3. Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II. Koe CT, et al. Elife, 2018 Feb 27. PMID 29482721, Free PMC Article
    4. Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. Terriente-Felix A, et al. PLoS Genet, 2020 Oct. PMID 33085661, Free PMC Article
    5. The class I PITP giotto is required for Drosophila cytokinesis. Giansanti MG, et al. Curr Biol, 2006 Jan 24. PMID 16431372

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
      Title: Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
    2. dPIP4K activity is a regulator of cell growth and TOR signaling during larval development
      Title: Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development.
    3. data suggest Fwd plays catalytic and noncatalytic roles in regulating Rab11 during cytokinesis
      Title: Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis II cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatocyte division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    four wheel drive
    Names
    CG7004-PA
    CG7004-PB
    CG7004-PC
    CG7004-PD
    CG7004-PE
    Four-wheel drive
    fwd-PA
    fwd-PB
    fwd-PC
    fwd-PD
    fwd-PE
    NP_001261203.1
    NP_001356971.1
    NP_524822.1
    NP_728518.1
    NP_728519.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      305393..319884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370043.1 → NP_001356971.1  four wheel drive, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K881
      Conserved Domains (1) summary
      cd05168
      Location:1385 → 1674
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    2. NM_080083.4 → NP_524822.1  four wheel drive, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960I2, Q9W0R8
      Related
      FBpp0072416
      Conserved Domains (1) summary
      cd05168
      Location:1385 → 1674
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    3. NM_167826.2 → NP_728518.1  four wheel drive, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960I2, Q9W0R8
      Related
      FBpp0072415
      Conserved Domains (1) summary
      cd05168
      Location:1385 → 1674
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    4. NM_001274274.1 → NP_001261203.1  four wheel drive, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960I2, Q9W0R8
      Conserved Domains (1) summary
      cd05168
      Location:1385 → 1674
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    5. NM_167827.2 → NP_728519.1  four wheel drive, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRJ1, Q9BKJ2
      Related
      FBpp0072417
      Conserved Domains (1) summary
      cd05168
      Location:1049 → 1338
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K881 A0A4D6K881
    Q9BKJ2 Q9BKJ2
    Q9W0R8 Q9W0R8

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