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    Sid Stress induced DNase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sidprovided by FlyBase
    Official Full Name
    Stress induced DNaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039593
    Locus tag
    Dmel_CG9989
    See related
    AllianceGenome:FB:FBgn0039593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9989; Dmel\CG9989; sid
    Summary
    Enables DNA nuclease activity and RNA nuclease activity. Involved in response to bacterium and response to oxidative stress. Located in cytoplasm and membrane. Is expressed in embryonic/larval fat body. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sid in Genome Data Viewer
    Location:
    98E1-98E1; 3-97 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28670704..28672021)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24496426..24497743)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene snustorr Neighboring gene huntingtin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel Drosophila stress induced DNase. Seong CS, et al. PLoS One, 2014. PMID 25083901, Free PMC Article
    2. Mammalian Models of Traumatic Brain Injury and a Place for Drosophila in TBI Research. Shah EJ, et al. Front Neurosci, 2019. PMID 31105519, Free PMC Article
    3. Domesticated gag Gene of Drosophila LTR Retrotransposons Is Involved in Response to Oxidative Stress. Makhnovskii P, et al. Genes (Basel), 2020 Apr 6. PMID 32268600, Free PMC Article
    4. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Brun S, et al. Genes Cells, 2006 Apr. PMID 16611243
    5. The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila. Agrawal P, et al. J Exp Biol, 2020 Jan 29. PMID 31900346, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stress induced DNase
    Names
    CG9989-PA
    Sid-PA
    NP_651627.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28670704..28672021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143370.2 → NP_651627.1  stress induced DNase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAU2
      Related
      FBpp0084676
      Conserved Domains (1) summary
      pfam01223
      Location:106 → 358
      Endonuclease_NS; DNA/RNA non-specific endonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAU2 Q9VAU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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